ID   IF5_TRICA               Reviewed;         162 AA.
AC   Q26891;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Eukaryotic translation initiation factor 5;
DE            Short=eIF-5;
DE   Flags: Fragment;
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=PRM;
RA   Braet Y., Haubruge E., Kettmann R., Gaspar C., Burny A.;
RT   "The eukaryotic translation initiation factor 5 corresponds to one gene
RT   differentially expressed during the ontogeny of red flour beetle (Tribolium
RT   castaneum Herbst; Coleoptera, Tenebrionidae).";
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal
CC       initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent
CC       joining of a 60S ribosomal subunit resulting in the release of eIF-2
CC       and the guanine nucleotide. The subsequent joining of a 60S ribosomal
CC       subunit results in the formation of a functional 80S initiation complex
CC       (80S.mRNA.Met-tRNA[F]) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family. {ECO:0000305}.
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DR   EMBL; Z69735; CAA93623.1; -; mRNA.
DR   AlphaFoldDB; Q26891; -.
DR   SMR; Q26891; -.
DR   STRING; 7070.TC007510-PA; -.
DR   PRIDE; Q26891; -.
DR   eggNOG; KOG2767; Eukaryota.
DR   HOGENOM; CLU_026663_1_0_1; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR045196; IF2/IF5.
DR   InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR   InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR   PANTHER; PTHR23001; PTHR23001; 1.
DR   Pfam; PF01873; eIF-5_eIF-2B; 1.
DR   SUPFAM; SSF75689; SSF75689; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Initiation factor; Nucleotide-binding; Protein biosynthesis.
FT   CHAIN           <1..>162
FT                   /note="Eukaryotic translation initiation factor 5"
FT                   /id="PRO_0000212521"
FT   REGION          59..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..134
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         162
SQ   SEQUENCE   162 AA;  18145 MW;  2124720737EC11E5 CRC64;
     VLLDGFIRKF VLCPECENPE TELLVSTKRS TISQGCKACG YHSPLESNHK LVTFILKNPP
     NLNPAVQGSS LTEGKRSKRS KRPNGDTNGD TSQVDDQNES LEASVNENSK NGDDDEGHEW
     QADVSEEAVR ARMQDLTEGA KNMTINDDLE KREKDRMDIF YE