ID   IF61_TRYCC              Reviewed;         248 AA.
AC   Q4E097;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN   Name=EIF6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN   ORFNames=Tc00.1047053506679.70;
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=353153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES 1 AND 2).
RC   STRAIN=CL Brener;
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M.A., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.-N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA   da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA   Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA   Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA   Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA   Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA   Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA   Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA   Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAN98181.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AAHK01000067; EAN98181.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_820032.1; XM_814939.1.
DR   AlphaFoldDB; Q4E097; -.
DR   SMR; Q4E097; -.
DR   STRING; 5693.XP_820032.1; -.
DR   PaxDb; Q4E097; -.
DR   EnsemblProtists; EAN98181; EAN98181; Tc00.1047053506679.70.
DR   GeneID; 3552617; -.
DR   KEGG; tcr:506679.70; -.
DR   eggNOG; KOG3185; Eukaryota.
DR   OrthoDB; 1157302at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW   Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..248
FT                   /note="Eukaryotic translation initiation factor 6"
FT                   /id="PRO_0000402104"
SQ   SEQUENCE   248 AA;  27076 MW;  60C19497677277E1 CRC64;
     MTLRTRFESS DDVGVFSRLT NAYCLVTAGG SQNFYSVFEQ ELANHIPVVY TSIGGSRVIG
     RLTCGNRHGL VVPSIATDQE LQHLRNSLPD SVKVQRVEER LNALGNCVVC NDHVALIHTD
     LSRETEEILR DTLQVQTFRT SIAENALVGS YAVVNNKGCM VHPKTPAQDM DEIASLLQVP
     VVAGTINRGN AAIGSGLVVN DWAAFCGLNT TATEITVVER IFQLRRDLGG DEPNLLQQLR
     DTLVDELA