IF6_AERPE
ID IF6_AERPE Reviewed; 233 AA.
AC Q9YD27;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_00032};
DE Short=aIF-6 {ECO:0000255|HAMAP-Rule:MF_00032};
GN Name=eif6 {ECO:0000255|HAMAP-Rule:MF_00032}; OrderedLocusNames=APE_1085;
OS Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS K1).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Aeropyrum.
OX NCBI_TaxID=272557;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT Aeropyrum pernix K1.";
RL DNA Res. 6:83-101(1999).
CC -!- FUNCTION: Binds to the 50S ribosomal subunit and prevents its
CC association with the 30S ribosomal subunit to form the 70S initiation
CC complex. {ECO:0000255|HAMAP-Rule:MF_00032}.
CC -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC Rule:MF_00032}.
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DR EMBL; BA000002; BAA80070.1; -; Genomic_DNA.
DR PIR; F72708; F72708.
DR AlphaFoldDB; Q9YD27; -.
DR SMR; Q9YD27; -.
DR STRING; 272557.APE_1085; -.
DR EnsemblBacteria; BAA80070; BAA80070; APE_1085.
DR KEGG; ape:APE_1085; -.
DR eggNOG; arCOG04176; Archaea.
DR OMA; GEDTTGP; -.
DR Proteomes; UP000002518; Chromosome.
DR GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042256; P:mature ribosome assembly; IEA:InterPro.
DR CDD; cd00527; IF6; 1.
DR HAMAP; MF_00032; eIF_6; 1.
DR InterPro; IPR002769; eIF6.
DR PANTHER; PTHR10784; PTHR10784; 1.
DR Pfam; PF01912; eIF-6; 1.
DR PIRSF; PIRSF006413; IF-6; 1.
DR SMART; SM00654; eIF6; 1.
DR TIGRFAMs; TIGR00323; eIF-6; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..233
FT /note="Translation initiation factor 6"
FT /id="PRO_0000153743"
SQ SEQUENCE 233 AA; 24276 MW; 29AA85A46CA8AE6D CRC64;
MSNGGSFTVE KLSLYGNPNI GVYLTASDSY VLAPDDIGAD DVRTISEVLG VAMERVVRLR
VLGMRLVGVL TTGNSRGILL PEGVDREVEL VRKALEGVEV GIVPTRSNAL GNVIVCNDRA
CLASPGLEKE ALKTVSDTLG VEVVEGSVAG VYTVGSAIVV TNRGGLAHPD ASEEELKFLS
DVFKVPFEAG TINFGVEFVR TGLVANSYGA LVGEDTTGPE IARIQVALGG GVK