IF6_BABBO
ID IF6_BABBO Reviewed; 249 AA.
AC A7ANL7;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 25-MAY-2022, entry version 47.
DE RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN Name=EIF6 {ECO:0000255|HAMAP-Rule:MF_03132}; ORFNames=BBOV_III005890;
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo;
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
CC -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC association with the 40S ribosomal subunit to form the 80S initiation
CC complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_03132}.
CC -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC {ECO:0000255|HAMAP-Rule:MF_03132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC Rule:MF_03132}.
CC -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC Rule:MF_03132}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDO08151.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAXT01000001; EDO08151.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; A7ANL7; -.
DR SMR; A7ANL7; -.
DR STRING; 5865.XP_001611719.1; -.
DR EnsemblProtists; EDO08151; EDO08151; BBOV_III005890.
DR VEuPathDB; PiroplasmaDB:BBOV_III005890; -.
DR eggNOG; KOG3185; Eukaryota.
DR InParanoid; A7ANL7; -.
DR Proteomes; UP000002173; Partially assembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd00527; IF6; 1.
DR HAMAP; MF_00032; eIF_6; 1.
DR InterPro; IPR002769; eIF6.
DR PANTHER; PTHR10784; PTHR10784; 1.
DR Pfam; PF01912; eIF-6; 1.
DR PIRSF; PIRSF006413; IF-6; 1.
DR SMART; SM00654; eIF6; 1.
DR TIGRFAMs; TIGR00323; eIF-6; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW Reference proteome; Ribosome biogenesis.
FT CHAIN 1..249
FT /note="Eukaryotic translation initiation factor 6"
FT /id="PRO_0000402101"
SQ SEQUENCE 249 AA; 27023 MW; B729DA475065E653 CRC64;
MAIRTQYENS NEVGVFATLT NSYALVSLGS SCNFASVFEA ELMPQIPVVQ TTIGGTRVVG
SVTVGNRKGL LVSSICTDTE LRHLRNSLPD SVEIRRIDDR LSALGNVITC NDYVGLIHVD
IDRETEEIVE DVLGIEVFRA SIAGNVLIGS YCRFQNKGGL VHVKTTTDEM EELSQLLQIP
LTSGTVNRGS DVIGGGLIAN DWVAFCGMST TATEIATIER IFQLSRPKEF DPSVSNSHTL
RNALIDTLI
