ID   IF6_CAEEL               Reviewed;         246 AA.
AC   O62106;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN   Name=eif-6 {ECO:0000255|HAMAP-Rule:MF_03132}; ORFNames=C47B2.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RX   PubMed=17507929; DOI=10.1038/nature05841;
RA   Chendrimada T.P., Finn K.J., Ji X., Baillat D., Gregory R.I.,
RA   Liebhaber S.A., Pasquinelli A.E., Shiekhattar R.;
RT   "MicroRNA silencing through RISC recruitment of eIF6.";
RL   Nature 447:823-828(2007).
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC       Involved in miRNA-mediated gene silencing (PubMed:17507929).
CC       {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:17507929}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
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DR   EMBL; Z99709; CAB16860.1; -; Genomic_DNA.
DR   PIR; T19988; T19988.
DR   RefSeq; NP_493272.1; NM_060871.5.
DR   AlphaFoldDB; O62106; -.
DR   SMR; O62106; -.
DR   BioGRID; 38566; 59.
DR   IntAct; O62106; 2.
DR   STRING; 6239.C47B2.5.2; -.
DR   iPTMnet; O62106; -.
DR   EPD; O62106; -.
DR   PaxDb; O62106; -.
DR   PeptideAtlas; O62106; -.
DR   EnsemblMetazoa; C47B2.5.1; C47B2.5.1; WBGene00001234.
DR   GeneID; 173169; -.
DR   KEGG; cel:CELE_C47B2.5; -.
DR   UCSC; C47B2.5.1; c. elegans.
DR   CTD; 173169; -.
DR   WormBase; C47B2.5; CE17565; WBGene00001234; eif-6.
DR   eggNOG; KOG3185; Eukaryota.
DR   GeneTree; ENSGT00390000015972; -.
DR   HOGENOM; CLU_071894_0_0_1; -.
DR   InParanoid; O62106; -.
DR   OMA; GEDTTGP; -.
DR   OrthoDB; 1157302at2759; -.
DR   PhylomeDB; O62106; -.
DR   PRO; PR:O62106; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00001234; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1902626; P:assembly of large subunit precursor of preribosome; IBA:GO_Central.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0035195; P:miRNA-mediated gene silencing; IMP:UniProtKB.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IBA:GO_Central.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW   Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..246
FT                   /note="Eukaryotic translation initiation factor 6"
FT                   /id="PRO_0000153736"
SQ   SEQUENCE   246 AA;  26308 MW;  D9DEAA42AE990253 CRC64;
     MALRVDYEGS NDVGVFCTLT NSYCLVGVGG TQNFYSILEA ELSDLIPVVH TSIASTRIVG
     RLTVGNRHGL LVPNATTDQE LQHLRNSLPD EVAIRRVDER LSALGNVIAC NDHVAIVHAE
     ISAETEQALV EVLKVEVFRV SLAQNSLVGS YCILSSNGCL VAARTPPETQ REIAALLQIP
     VVAGTCNRGS ELIGAGMVVN DWVAFCGLDS TSTELSVVES IFKLGEQGAP TSISNQLRDT
     LIESML