IF6_DICDI
ID IF6_DICDI Reviewed; 244 AA.
AC Q551M2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN Name=eif6; ORFNames=DDB_G0276493;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC association with the 40S ribosomal subunit to form the 80S initiation
CC complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_03132}.
CC -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC {ECO:0000255|HAMAP-Rule:MF_03132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC Rule:MF_03132}.
CC -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC Rule:MF_03132}.
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DR EMBL; AAFI02000015; EAL69200.1; -; Genomic_DNA.
DR RefSeq; XP_643108.1; XM_638016.1.
DR PDB; 5AN9; EM; 3.30 A; I=1-224.
DR PDB; 5ANB; EM; 4.10 A; I=1-224.
DR PDB; 6QKL; EM; 3.30 A; I=1-224.
DR PDBsum; 5AN9; -.
DR PDBsum; 5ANB; -.
DR PDBsum; 6QKL; -.
DR AlphaFoldDB; Q551M2; -.
DR SMR; Q551M2; -.
DR STRING; 44689.DDB0234038; -.
DR PaxDb; Q551M2; -.
DR EnsemblProtists; EAL69200; EAL69200; DDB_G0276493.
DR GeneID; 8620512; -.
DR KEGG; ddi:DDB_G0276493; -.
DR dictyBase; DDB_G0276493; eIF6.
DR eggNOG; KOG3185; Eukaryota.
DR HOGENOM; CLU_071894_0_0_1; -.
DR InParanoid; Q551M2; -.
DR OMA; GEDTTGP; -.
DR PhylomeDB; Q551M2; -.
DR PRO; PR:Q551M2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IDA:dictyBase.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0043023; F:ribosomal large subunit binding; IDA:dictyBase.
DR GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:1902626; P:assembly of large subunit precursor of preribosome; IBA:GO_Central.
DR GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:dictyBase.
DR GO; GO:0000054; P:ribosomal subunit export from nucleus; IBA:GO_Central.
DR CDD; cd00527; IF6; 1.
DR HAMAP; MF_00032; eIF_6; 1.
DR InterPro; IPR002769; eIF6.
DR PANTHER; PTHR10784; PTHR10784; 1.
DR Pfam; PF01912; eIF-6; 1.
DR PIRSF; PIRSF006413; IF-6; 1.
DR SMART; SM00654; eIF6; 1.
DR TIGRFAMs; TIGR00323; eIF-6; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW Reference proteome; Ribosome biogenesis.
FT CHAIN 1..244
FT /note="Eukaryotic translation initiation factor 6"
FT /id="PRO_0000320058"
FT STRAND 2..4
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 14..19
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 24..26
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 32..40
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 44..46
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 60..62
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 78..87
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 90..96
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 104..107
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 112..116
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 123..133
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 135..137
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 149..151
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 152..154
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 159..161
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 167..177
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 186..189
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 193..196
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 197..199
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 204..206
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 212..222
FT /evidence="ECO:0007829|PDB:5AN9"
SQ SEQUENCE 244 AA; 26254 MW; 7C72A4210AE1EB2C CRC64;
MATRLQYENS CDVGVFLKLT NKYCLVGQCG SKQFLHTVEN RLADHIPVVE TSIAGTRIVG
RLSAGNKNGL LLPNTCTDQE LQQIRNSLPD DVVVQRIEEK FSALGNCIAT NDYVALVHPD
IDRETEEIIA DVLGVEVFRQ TVSGNVLVGT YCALTNQGAL VHPMTSIADQ DELSSLLQVP
LVAGTVNRGN ECVAAGCVVN DWTAIVGADT TATEISVIES IFALQGSKPS NIINNIRNSI
VDNV
