ID   IF6_ENTDS               Reviewed;         239 AA.
AC   B0EMY3;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN   Name=EIF6 {ECO:0000255|HAMAP-Rule:MF_03132}; ORFNames=EDI_198960;
OS   Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370354;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-260 / SAW760;
RA   Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT   "Annotation of Entamoeba dispar SAW760.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDR24107.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DS550044; EDR24107.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001739507.1; XM_001739455.1.
DR   AlphaFoldDB; B0EMY3; -.
DR   SMR; B0EMY3; -.
DR   STRING; 46681.XP_001739507.1; -.
DR   EnsemblProtists; EDR24107; EDR24107; EDI_198960.
DR   GeneID; 5884642; -.
DR   KEGG; edi:EDI_198960; -.
DR   eggNOG; KOG3185; Eukaryota.
DR   OrthoDB; 1157302at2759; -.
DR   Proteomes; UP000008076; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW   Ribosome biogenesis.
FT   CHAIN           1..239
FT                   /note="Eukaryotic translation initiation factor 6"
FT                   /id="PRO_0000402099"
SQ   SEQUENCE   239 AA;  25882 MW;  00D5B050FDB4CEAC CRC64;
     MALRAEYENS ADIGVFTKLT NKYCITAPGG SSSYKIIEQE VSPKIPCVEA TIGGLRIIGR
     LAVGNRKGLL LPNTCNDQEL LHLRNSLPDD VVVQRVEERM SALGNCIACN DYVALVHPEI
     DRETEEIIAD VLGVEVFRHA VGGNPLVGTY SVITNKGAML APNTTQQEQE EIGTILQVPL
     VAGTVNRGSN LLGSGMIVND WCGFVGMDTT ATELSIVEGI YKLRNETDVQ FASVMELMK