IF6_GUITH
ID IF6_GUITH Reviewed; 228 AA.
AC Q98RM8;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN Name=EIF6 {ECO:0000255|HAMAP-Rule:MF_03132};
OS Guillardia theta (Cryptophyte) (Cryptomonas phi).
OG Nucleomorph.
OC Eukaryota; Cryptophyceae; Pyrenomonadales; Geminigeraceae; Guillardia.
OX NCBI_TaxID=55529;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11323671; DOI=10.1038/35074092;
RA Douglas S.E., Zauner S., Fraunholz M., Beaton M., Penny S.L., Deng L.-T.,
RA Wu X., Reith M.E., Cavalier-Smith T., Maier U.-G.;
RT "The highly reduced genome of an enslaved algal nucleus.";
RL Nature 410:1091-1096(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10618395; DOI=10.1073/pnas.97.1.200;
RA Zauner S., Fraunholz M., Wastl J., Penny S.L., Beaton M.,
RA Cavalier-Smith T., Maier U.-G., Douglas S.E.;
RT "Chloroplast protein and centrosomal genes, a tRNA intron, and odd
RT telomeres in an unusually compact eukaryotic genome, the cryptomonad
RT nucleomorph.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:200-205(2000).
CC -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC association with the 40S ribosomal subunit to form the 80S initiation
CC complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_03132}.
CC -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC {ECO:0000255|HAMAP-Rule:MF_03132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC Rule:MF_03132}.
CC -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC Rule:MF_03132}.
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DR EMBL; AF165818; AAK39919.1; -; Genomic_DNA.
DR PIR; H90098; H90098.
DR RefSeq; XP_001713624.1; XM_001713572.1.
DR AlphaFoldDB; Q98RM8; -.
DR SMR; Q98RM8; -.
DR GeneID; 857406; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00032; eIF_6; 1.
DR InterPro; IPR002769; eIF6.
DR PANTHER; PTHR10784; PTHR10784; 1.
DR Pfam; PF01912; eIF-6; 1.
DR PIRSF; PIRSF006413; IF-6; 1.
DR SMART; SM00654; eIF6; 1.
DR TIGRFAMs; TIGR00323; eIF-6; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW Ribosome biogenesis.
FT CHAIN 1..228
FT /note="Eukaryotic translation initiation factor 6"
FT /id="PRO_0000402103"
SQ SEQUENCE 228 AA; 25170 MW; 632EA7B692B262A0 CRC64;
MTIKLNLYGK EDIGNYILLT NSYCIVPHDI NSKNYNIIKS ELDNKINIIC TNVSESICVG
NLLIGNSKGL IVPNTITFHE QNELLNFLPE KVLVKKFNEN LTNLGNLLAH NELYGLSSPD
LSQSSCELIS DVLGVEILKL TLGEEKMIGT YCKFNINGGI VQPFLSIEDH DELVEITGVP
FIGGTVNSGC SNVGKGIVCN DNLVFCGYKT NQTEMHIINN IMKKSKNK
