ID   IF6_METBF               Reviewed;         219 AA.
AC   Q46FA1;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_00032};
DE            Short=aIF-6 {ECO:0000255|HAMAP-Rule:MF_00032};
GN   Name=eif6 {ECO:0000255|HAMAP-Rule:MF_00032}; OrderedLocusNames=Mbar_A0459;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fusaro / DSM 804;
RX   PubMed=16980466; DOI=10.1128/jb.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA   Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- FUNCTION: Binds to the 50S ribosomal subunit and prevents its
CC       association with the 30S ribosomal subunit to form the 70S initiation
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00032}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00032}.
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DR   EMBL; CP000099; AAZ69441.1; -; Genomic_DNA.
DR   RefSeq; WP_011305493.1; NC_007355.1.
DR   AlphaFoldDB; Q46FA1; -.
DR   SMR; Q46FA1; -.
DR   STRING; 269797.Mbar_A0459; -.
DR   EnsemblBacteria; AAZ69441; AAZ69441; Mbar_A0459.
DR   GeneID; 3624335; -.
DR   KEGG; mba:Mbar_A0459; -.
DR   eggNOG; arCOG04176; Archaea.
DR   HOGENOM; CLU_071894_1_0_2; -.
DR   OMA; GEDTTGP; -.
DR   OrthoDB; 70525at2157; -.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:InterPro.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis.
FT   CHAIN           1..219
FT                   /note="Translation initiation factor 6"
FT                   /id="PRO_0000259429"
SQ   SEQUENCE   219 AA;  22955 MW;  8CBF0736E30AC8D4 CRC64;
     MIRTVDIYDT PMIGVFATCT EDVVLVPTGT KPETCAILED SLDARIVETL VNGSVVIGAL
     SRGNSNGFLY SYGTDAGEMK ELTGVEAEIL PGKLNAVGNI VLANDSAALV HPELSDKAIE
     VIASTLKVEV YRGTIAGIKN VGMAGVVTNK GLLVHPKVTA SEIETLEKLF ELPVNIGTTN
     FGTQMLGSGL LANSKNYLAG SDTTGPELGR IEEALGFLE