ID   IF6_METTH               Reviewed;         222 AA.
AC   O27648;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_00032};
DE            Short=aIF-6 {ECO:0000255|HAMAP-Rule:MF_00032};
GN   Name=eif6 {ECO:0000255|HAMAP-Rule:MF_00032}; OrderedLocusNames=MTH_1611;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Binds to the 50S ribosomal subunit and prevents its
CC       association with the 30S ribosomal subunit to form the 70S initiation
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00032}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00032}.
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DR   EMBL; AE000666; AAB86084.1; -; Genomic_DNA.
DR   PIR; C69082; C69082.
DR   RefSeq; WP_010877219.1; NC_000916.1.
DR   PDB; 4ADX; EM; 6.60 A; I=1-222.
DR   PDBsum; 4ADX; -.
DR   AlphaFoldDB; O27648; -.
DR   SMR; O27648; -.
DR   STRING; 187420.MTH_1611; -.
DR   EnsemblBacteria; AAB86084; AAB86084; MTH_1611.
DR   GeneID; 24854713; -.
DR   KEGG; mth:MTH_1611; -.
DR   PATRIC; fig|187420.15.peg.1575; -.
DR   HOGENOM; CLU_071894_1_0_2; -.
DR   OMA; GEDTTGP; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:InterPro.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..222
FT                   /note="Translation initiation factor 6"
FT                   /id="PRO_0000153750"
SQ   SEQUENCE   222 AA;  22658 MW;  B86780BEC5C82533 CRC64;
     MIRRINLSGN PNLGVYISVT DSVALIPQNT PEKFEGVLRE ALEVEVLKVS ISGSSLNGAL
     AVGNSNGFVV SNQAMDREID ALAAAGVEAV RIPERFTAVG NLVLANDNGA VASPLLSDDA
     LQVIGDVLEV DVKVSTLAGL NIVGSMGAAT NRGALLNPQA SSEEIGIIED TLGVEADVGT
     VNHGVTLIGA CSVANSNGVL VGEETTGPEL ARIEEALGFL EG