ID   IF6_OSTLU               Reviewed;         245 AA.
AC   A4RSQ6;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN   Name=EIF6 {ECO:0000255|HAMAP-Rule:MF_03132}; ORFNames=OSTLU_119613;
OS   Ostreococcus lucimarinus (strain CCE9901).
OC   Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC   Bathycoccaceae; Ostreococcus; unclassified Ostreococcus.
OX   NCBI_TaxID=436017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCE9901;
RX   PubMed=17460045; DOI=10.1073/pnas.0611046104;
RA   Palenik B., Grimwood J., Aerts A., Rouze P., Salamov A., Putnam N.,
RA   Dupont C., Jorgensen R., Derelle E., Rombauts S., Zhou K., Otillar R.,
RA   Merchant S.S., Podell S., Gaasterland T., Napoli C., Gendler K.,
RA   Manuell A., Tai V., Vallon O., Piganeau G., Jancek S., Heijde M.,
RA   Jabbari K., Bowler C., Lohr M., Robbens S., Werner G., Dubchak I.,
RA   Pazour G.J., Ren Q., Paulsen I., Delwiche C., Schmutz J., Rokhsar D.,
RA   Van de Peer Y., Moreau H., Grigoriev I.V.;
RT   "The tiny eukaryote Ostreococcus provides genomic insights into the paradox
RT   of plankton speciation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:7705-7710(2007).
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABO94498.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CP000582; ABO94498.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001416205.1; XM_001416168.1.
DR   AlphaFoldDB; A4RSQ6; -.
DR   SMR; A4RSQ6; -.
DR   STRING; 436017.A4RSQ6; -.
DR   GeneID; 5000461; -.
DR   KEGG; olu:OSTLU_119613; -.
DR   eggNOG; KOG3185; Eukaryota.
DR   HOGENOM; CLU_071894_0_0_1; -.
DR   OrthoDB; 1157302at2759; -.
DR   Proteomes; UP000001568; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW   Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..245
FT                   /note="Eukaryotic translation initiation factor 6"
FT                   /id="PRO_0000402100"
SQ   SEQUENCE   245 AA;  26142 MW;  4D1807A82890616B CRC64;
     MAARHQFENS NEIGVFAALT NAYCLAAVGG SENFYSVFEA ELSNEIPVIK ASLAGTRLVG
     RLSVGNKHGL LLPTSATDQE VMHIRNSLPD EVIVQRTEER LSALGNCVAC NDHVALVHPD
     IDQETEEIIA DVLGVEVFRQ SVAGNVLVGS FCKFSNRGGM VHPQASVQEV DELSSLLQVP
     LVAGTINRGS DVIGAGLLVN DWIAFCGLDT TSTEIQVIES IYQLHGADSS GAVRDIRASL
     LDTLV