ID   IF6_PYRAB               Reviewed;         227 AA.
AC   Q9UYI6; G8ZIU2;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_00032};
DE            Short=aIF-6 {ECO:0000255|HAMAP-Rule:MF_00032};
GN   Name=eif6 {ECO:0000255|HAMAP-Rule:MF_00032}; OrderedLocusNames=PYRAB15210;
GN   ORFNames=PAB1005;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- FUNCTION: Binds to the 50S ribosomal subunit and prevents its
CC       association with the 30S ribosomal subunit to form the 70S initiation
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00032}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00032}.
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DR   EMBL; AJ248287; CAB50426.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70975.1; -; Genomic_DNA.
DR   PIR; E75066; E75066.
DR   RefSeq; WP_010868639.1; NC_000868.1.
DR   AlphaFoldDB; Q9UYI6; -.
DR   SMR; Q9UYI6; -.
DR   STRING; 272844.PAB1005; -.
DR   PRIDE; Q9UYI6; -.
DR   EnsemblBacteria; CAB50426; CAB50426; PAB1005.
DR   GeneID; 1495804; -.
DR   KEGG; pab:PAB1005; -.
DR   PATRIC; fig|272844.11.peg.1620; -.
DR   eggNOG; arCOG04176; Archaea.
DR   HOGENOM; CLU_071894_1_0_2; -.
DR   OMA; GEDTTGP; -.
DR   OrthoDB; 70525at2157; -.
DR   PhylomeDB; Q9UYI6; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:InterPro.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis.
FT   CHAIN           1..227
FT                   /note="Translation initiation factor 6"
FT                   /id="PRO_0000153753"
SQ   SEQUENCE   227 AA;  24693 MW;  1C8F1D8C960F54FE CRC64;
     MHIERLDFEN SPYLGVFGVA TDRVVLVREG LQEKKLEVIR EVLKVPVIEA SIMKSRIIGT
     LATGNSNAIL VPWYVWDTEI ERIKSAFKEY GIETEIVPFR TKYTALGNLI LTNDKAALVS
     AKFSRDEAKE IGDILGVEVE RGLIAGLHAV GSAGVVTNKG GLVHPEASDE ELEWLSELFK
     VDVYVGTANM GVPYVGTCML ANSNGVVVGH LTTGPEIVKI EEALGLI