ID   IF6_PYRFU               Reviewed;         227 AA.
AC   Q8U3S8;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_00032};
DE            Short=aIF-6 {ECO:0000255|HAMAP-Rule:MF_00032};
GN   Name=eif6 {ECO:0000255|HAMAP-Rule:MF_00032}; OrderedLocusNames=PF0377;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- FUNCTION: Binds to the 50S ribosomal subunit and prevents its
CC       association with the 30S ribosomal subunit to form the 70S initiation
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00032}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00032}.
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DR   EMBL; AE009950; AAL80501.1; -; Genomic_DNA.
DR   RefSeq; WP_011011491.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8U3S8; -.
DR   SMR; Q8U3S8; -.
DR   STRING; 186497.PF0377; -.
DR   EnsemblBacteria; AAL80501; AAL80501; PF0377.
DR   GeneID; 41712157; -.
DR   KEGG; pfu:PF0377; -.
DR   PATRIC; fig|186497.12.peg.392; -.
DR   eggNOG; arCOG04176; Archaea.
DR   HOGENOM; CLU_071894_1_0_2; -.
DR   OMA; GEDTTGP; -.
DR   OrthoDB; 70525at2157; -.
DR   PhylomeDB; Q8U3S8; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:InterPro.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..227
FT                   /note="Translation initiation factor 6"
FT                   /id="PRO_0000153755"
SQ   SEQUENCE   227 AA;  24593 MW;  1C9398E7EFB76E69 CRC64;
     MHIEKLDFEN SPYLGVFGIA TDKVVLIREG LQEKKLEVIR EVLKVPVVEA SLMKSRIIGV
     LGAGNSNAII VPWYVWDSEL EKIKNAFREY GIDTEVVPFQ TKYTALGNLI LTNDKGALVS
     SKFSREEAKK IGDILGVEVE RGVIAGIVAV GSAGVVTNKG GLVHPEATDE ELEWLSDLFK
     VDVYVGTANM GVPYVGSCML ANSYGVVVGH LTTGPEIVKI EEALGFI