ID   IF6_SORMK               Reviewed;         246 AA.
AC   D1ZG64; F7VSC9;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN   Name=TIF6 {ECO:0000255|HAMAP-Rule:MF_03132}; ORFNames=SMAC_01959;
OS   Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX   NCBI_TaxID=771870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell;
RX   PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA   Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K.,
RA   Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S.,
RA   Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.;
RT   "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT   Sordaria macrospora, a model organism for fungal morphogenesis.";
RL   PLoS Genet. 6:E1000891-E1000891(2010).
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. Is also involved in ribosome biogenesis.
CC       Associates with pre-60S subunits in the nucleus and is involved in its
CC       nuclear export. {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- PTM: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCC08415.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CCC08415.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CABT02000005; CCC08415.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; D1ZG64; -.
DR   SMR; D1ZG64; -.
DR   STRING; 771870.D1ZG64; -.
DR   EnsemblFungi; CCC08415; CCC08415; SMAC_01959.
DR   eggNOG; KOG3185; Eukaryota.
DR   HOGENOM; CLU_071894_0_0_1; -.
DR   InParanoid; D1ZG64; -.
DR   OrthoDB; 1157302at2759; -.
DR   Proteomes; UP000001881; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Nucleus; Phosphoprotein;
KW   Protein biosynthesis; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..246
FT                   /note="Eukaryotic translation initiation factor 6"
FT                   /id="PRO_0000402110"
FT   MOD_RES         174
FT                   /note="Phosphoserine; by CK1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03132"
FT   MOD_RES         175
FT                   /note="Phosphoserine; by CK1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03132"
SQ   SEQUENCE   246 AA;  26516 MW;  36E1058158E401F0 CRC64;
     MAVRAQFENS NEVGVFSTLT NSYALVAVGA SENFYSVFEA ELQDVIPICR TTIAGTRIIG
     RLTAGNRKGL LVPTSTSDQE LQHLRNSLPD DVRIQRIEER LSALGNVIVC NDHTALIHPD
     LERETEEIIA DVLGVEVFRQ TIADNVLVGS YMSLSNQGGL VHPKTSIQDQ DELSSLLQVP
     LVAGSVNRGS NVIGGGMVVN DWMAVTGLDT TAPELSVIES VFRLGEGAAP GQINSSLKDT
     MVESFY