ID   IF6_TALSN               Reviewed;         247 AA.
AC   B8MDN4; B8MDN5;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN   Name=tif6; ORFNames=TSTA_120150;
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. Is also involved in ribosome biogenesis.
CC       Associates with pre-60S subunits in the nucleus and is involved in its
CC       nuclear export. {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- PTM: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EED18264.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EED18265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; EQ962655; EED18263.1; -; Genomic_DNA.
DR   EMBL; EQ962655; EED18264.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; EQ962655; EED18265.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002482255.1; XM_002482210.1.
DR   RefSeq; XP_002482256.1; XM_002482211.1.
DR   RefSeq; XP_002482257.1; XM_002482212.1.
DR   AlphaFoldDB; B8MDN4; -.
DR   SMR; B8MDN4; -.
DR   STRING; 441959.B8MDN4; -.
DR   EnsemblFungi; EED18263; EED18263; TSTA_120150.
DR   EnsemblFungi; EED18264; EED18264; TSTA_120150.
DR   EnsemblFungi; EED18265; EED18265; TSTA_120150.
DR   GeneID; 8105289; -.
DR   VEuPathDB; FungiDB:TSTA_120150; -.
DR   eggNOG; KOG3185; Eukaryota.
DR   HOGENOM; CLU_071894_0_0_1; -.
DR   InParanoid; B8MDN4; -.
DR   OMA; GEDTTGP; -.
DR   OrthoDB; 1157302at2759; -.
DR   PhylomeDB; B8MDN4; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Nucleus; Phosphoprotein;
KW   Protein biosynthesis; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..247
FT                   /note="Eukaryotic translation initiation factor 6"
FT                   /id="PRO_0000402111"
FT   MOD_RES         174
FT                   /note="Phosphoserine; by CK1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03132"
FT   MOD_RES         175
FT                   /note="Phosphoserine; by CK1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03132"
SQ   SEQUENCE   247 AA;  26430 MW;  6E7B3792BC19C52B CRC64;
     MAVRAQFENS NEVGVFATLT NSYAIVAIGG SENFYSVFEA ELQDVIPICH ASIGGTRIVG
     RLTAGNRKGL LVPTSTTDQE LQHLRNSIPD SVKIQRVEER LSALGNVICC NDHVALIHPD
     LERETEEIIA DVLGVEVFRQ TVADNVLTGS YMALSNQGGI VHPKTSIRDQ DELSSLLQVP
     LVAGSVNRGS PVVGAGMVVN DWLAVTGLDT TATELSVMES VFRLGEMGAK GLGMGNANKE
     SIVESFY