ID   IF6_THEKO               Reviewed;         229 AA.
AC   Q5JGT4;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_00032};
DE            Short=aIF-6 {ECO:0000255|HAMAP-Rule:MF_00032};
GN   Name=eif6 {ECO:0000255|HAMAP-Rule:MF_00032}; OrderedLocusNames=TK1321;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Binds to the 50S ribosomal subunit and prevents its
CC       association with the 30S ribosomal subunit to form the 70S initiation
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00032}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00032}.
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DR   EMBL; AP006878; BAD85510.1; -; Genomic_DNA.
DR   RefSeq; WP_011250272.1; NC_006624.1.
DR   AlphaFoldDB; Q5JGT4; -.
DR   SMR; Q5JGT4; -.
DR   STRING; 69014.TK1321; -.
DR   EnsemblBacteria; BAD85510; BAD85510; TK1321.
DR   GeneID; 3234216; -.
DR   KEGG; tko:TK1321; -.
DR   PATRIC; fig|69014.16.peg.1293; -.
DR   eggNOG; arCOG04176; Archaea.
DR   HOGENOM; CLU_071894_1_0_2; -.
DR   InParanoid; Q5JGT4; -.
DR   OMA; GEDTTGP; -.
DR   OrthoDB; 70525at2157; -.
DR   PhylomeDB; Q5JGT4; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1902626; P:assembly of large subunit precursor of preribosome; IBA:GO_Central.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:InterPro.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..229
FT                   /note="Translation initiation factor 6"
FT                   /id="PRO_0000153757"
SQ   SEQUENCE   229 AA;  24984 MW;  77F190B2DB86DDE2 CRC64;
     MHIERLDFEN SPYLGVYGRA TDRVLLLREG LGEKKLEVLR EVLKVPIIET SIMKSRIVGI
     FAAGNSNAII VPWYIWDAEL ERIKTALNEF GIDMDVVPFK SRLTALGNLI LTNDKAALVS
     KEFTREEANA IGEILGVDEV ERGMIASYRS VGSVGVVTNK GGLVHPEATD EELEWLSDLF
     GVDIYVGTAN MGVPFVGSCM LANSYGVVVG HLTTGPEIVK IEEALGFLG