ID   IF6_THEON               Reviewed;         228 AA.
AC   B6YWY2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_00032};
DE            Short=aIF-6 {ECO:0000255|HAMAP-Rule:MF_00032};
GN   Name=eif6 {ECO:0000255|HAMAP-Rule:MF_00032}; OrderedLocusNames=TON_1107;
OS   Thermococcus onnurineus (strain NA1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=523850;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1;
RX   PubMed=18790866; DOI=10.1128/jb.00746-08;
RA   Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H.,
RA   Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J.,
RA   Colwell R.R., Kim S.-J., Lee J.-H.;
RT   "The complete genome sequence of Thermococcus onnurineus NA1 reveals a
RT   mixed heterotrophic and carboxydotrophic metabolism.";
RL   J. Bacteriol. 190:7491-7499(2008).
CC   -!- FUNCTION: Binds to the 50S ribosomal subunit and prevents its
CC       association with the 30S ribosomal subunit to form the 70S initiation
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00032}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00032}.
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DR   EMBL; CP000855; ACJ16595.1; -; Genomic_DNA.
DR   RefSeq; WP_012572067.1; NC_011529.1.
DR   AlphaFoldDB; B6YWY2; -.
DR   SMR; B6YWY2; -.
DR   STRING; 523850.TON_1107; -.
DR   EnsemblBacteria; ACJ16595; ACJ16595; TON_1107.
DR   GeneID; 7018129; -.
DR   KEGG; ton:TON_1107; -.
DR   PATRIC; fig|523850.10.peg.1115; -.
DR   eggNOG; arCOG04176; Archaea.
DR   HOGENOM; CLU_071894_1_0_2; -.
DR   OMA; GEDTTGP; -.
DR   OrthoDB; 70525at2157; -.
DR   Proteomes; UP000002727; Chromosome.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:InterPro.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis.
FT   CHAIN           1..228
FT                   /note="Translation initiation factor 6"
FT                   /id="PRO_1000090396"
SQ   SEQUENCE   228 AA;  25118 MW;  6A2291F952B414A1 CRC64;
     MHIEKLDFEN SPYLGVYGTA TDRVALIREG LGEKKLEVLR EVLKVPLIET SIMKSRIVGV
     FAAGNSNAIV VPWYIWDAEL EHIQNELNEL DIDMRIEPFQ STLTAFGNLI LANDKAALIS
     VKFTREEAKK LEDILGVEVE RGMIGDYHAV GSVGVVTNRG GLVHPEATDE ELEWLRDLFK
     VDIYVGTANM GVPFVGSCML ANSHGVVVGH LTTGPEIVKI EEALGFLD