ID   IF6_THEPD               Reviewed;         223 AA.
AC   A1RXF3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_00032};
DE            Short=aIF-6 {ECO:0000255|HAMAP-Rule:MF_00032};
GN   Name=eif6 {ECO:0000255|HAMAP-Rule:MF_00032}; OrderedLocusNames=Tpen_0474;
OS   Thermofilum pendens (strain DSM 2475 / Hrk 5).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermofilales; Thermofilaceae;
OC   Thermofilum.
OX   NCBI_TaxID=368408;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2475 / Hrk 5;
RX   PubMed=18263724; DOI=10.1128/jb.01949-07;
RA   Anderson I., Rodriguez J., Susanti D., Porat I., Reich C., Ulrich L.E.,
RA   Elkins J.G., Mavromatis K., Lykidis A., Kim E., Thompson L.S., Nolan M.,
RA   Land M., Copeland A., Lapidus A., Lucas S., Detter C., Zhulin I.B.,
RA   Olsen G.J., Whitman W., Mukhopadhyay B., Bristow J., Kyrpides N.;
RT   "Genome sequence of Thermofilum pendens reveals an exceptional loss of
RT   biosynthetic pathways without genome reduction.";
RL   J. Bacteriol. 190:2957-2965(2008).
CC   -!- FUNCTION: Binds to the 50S ribosomal subunit and prevents its
CC       association with the 30S ribosomal subunit to form the 70S initiation
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00032}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00032}.
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DR   EMBL; CP000505; ABL77883.1; -; Genomic_DNA.
DR   RefSeq; WP_011752148.1; NC_008698.1.
DR   AlphaFoldDB; A1RXF3; -.
DR   SMR; A1RXF3; -.
DR   STRING; 368408.Tpen_0474; -.
DR   EnsemblBacteria; ABL77883; ABL77883; Tpen_0474.
DR   GeneID; 4602033; -.
DR   KEGG; tpe:Tpen_0474; -.
DR   eggNOG; arCOG04176; Archaea.
DR   HOGENOM; CLU_071894_1_0_2; -.
DR   OMA; GEDTTGP; -.
DR   OrthoDB; 70525at2157; -.
DR   Proteomes; UP000000641; Chromosome.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:InterPro.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..223
FT                   /note="Translation initiation factor 6"
FT                   /id="PRO_1000002605"
SQ   SEQUENCE   223 AA;  23959 MW;  D492A728FF6FD163 CRC64;
     MVNVEAISLY GTPNIGVYIF ANDRFALIPY DAPEKLDRKI AENLSVDAFR VSVAGTRLVG
     IFLAGNNNGL VVPRVILDSE LEHLKSLLDV NIVVLEDVRE TGIGNLVLAN DNGCVASQIL
     PKSAVDRIAD ALGVECIQMS IGDVPFVGSL SVATNRGVAL PPLATEEEIK SVEEALKVKA
     NVLTVNRGKM FLRTGLVANS KGALVGEDTT GHEMMQLQRI FFQ