ID   IF6_TOXGV               Reviewed;         264 AA.
AC   B9PVB9; B6KPW9; B9QI57;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 3.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN   Name=EIF6 {ECO:0000255|HAMAP-Rule:MF_03132}; ORFNames=TGVEG_318700;
OS   Toxoplasma gondii (strain ATCC 50861 / VEG).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=432359;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50861 / VEG;
RA   Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT   "Annotation of Toxoplasma gondii VEG.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
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DR   EMBL; AAYL02000285; ESS29715.1; -; Genomic_DNA.
DR   AlphaFoldDB; B9PVB9; -.
DR   SMR; B9PVB9; -.
DR   STRING; 5811.TGME49_118700; -.
DR   EnsemblProtists; ESS29715; ESS29715; TGVEG_318700.
DR   EnsemblProtists; TGME49_318700-t26_1; TGME49_318700-t26_1; TGME49_318700.
DR   VEuPathDB; ToxoDB:TGVEG_318700; -.
DR   eggNOG; KOG3185; Eukaryota.
DR   InParanoid; B9PVB9; -.
DR   Proteomes; UP000002226; Partially assembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW   Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..264
FT                   /note="Eukaryotic translation initiation factor 6"
FT                   /id="PRO_0000402102"
SQ   SEQUENCE   264 AA;  28573 MW;  C5588742EB3C4EA9 CRC64;
     MNASCAALWS LGSSRMATRA QFESSNEVGV FAKLTNSYCL VALGGSEHFY STLEAELAPH
     IPVVHATVGG TRVIGRVCVG NRRGLIVPSI TTDQELQHLR NSLPDSVEIR RVEERLSALG
     NNVACNDYVA LLHTDMDKET EEIVQDVLGV EAFRATIGKQ TLVGSYCHFT NQGGLVHVMT
     PVEDMEELSQ LLQVPLTAGT VNRGSDLVGA GLIANDWAAF CGMDTTATEL AVVERIFKIA
     TRNQQKLNLV DDLTLRSSLI DTLS