ID   IF6_TRYCR               Reviewed;         114 AA.
AC   Q9XYP3;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Eukaryotic translation initiation factor 6;
DE            Short=eIF-6;
DE   Flags: Fragment;
OS   Trypanosoma cruzi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=5693;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tulahuen;
RA   Lorenzi H., Catalani M., Levin M.J.;
RT   "T. cruzi SZ5 locus DNA.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. May also be involved in ribosome biogenesis
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus/nucleolus.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000305}.
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DR   EMBL; AF117890; AAD24769.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9XYP3; -.
DR   SMR; Q9XYP3; -.
DR   VEuPathDB; TriTrypDB:BCY84_16188; -.
DR   VEuPathDB; TriTrypDB:C3747_7g428; -.
DR   VEuPathDB; TriTrypDB:C4B63_13g230; -.
DR   VEuPathDB; TriTrypDB:Tc_MARK_8534; -.
DR   VEuPathDB; TriTrypDB:TcBrA4_0004090; -.
DR   VEuPathDB; TriTrypDB:TcCL_NonESM10874; -.
DR   VEuPathDB; TriTrypDB:TcCLB.506679.70; -.
DR   VEuPathDB; TriTrypDB:TCDM_01143; -.
DR   VEuPathDB; TriTrypDB:TcG_09439; -.
DR   VEuPathDB; TriTrypDB:TCSYLVIO_009989; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0079840; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:InterPro.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   SMART; SM00654; eIF6; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW   Ribosome biogenesis.
FT   CHAIN           <1..114
FT                   /note="Eukaryotic translation initiation factor 6"
FT                   /id="PRO_0000153738"
FT   NON_TER         1
SQ   SEQUENCE   114 AA;  12083 MW;  63671F07F6C532B3 CRC64;
     GTTFRTSIAE NALVGSYAVV NNKGCMVHPK TPAQDMDEIA SLLQVPVVAG TINRGNAAIG
     SGLVVNDWAA FCGLNTTATE ITVVERIFQL RRDLGGGRAN LLQQLRDTLV DELA