位置:首页 > 蛋白库 > IF6_VERA1
IF6_VERA1
ID   IF6_VERA1               Reviewed;         246 AA.
AC   C9SV08;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN   Name=TIF6 {ECO:0000255|HAMAP-Rule:MF_03132}; ORFNames=VDBG_08733;
OS   Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)
OS   (Verticillium wilt of alfalfa) (Verticillium albo-atrum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=526221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VaMs.102 / ATCC MYA-4576 / FGSC 10136;
RX   PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA   Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA   Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA   Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA   Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA   Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA   Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT   "Comparative genomics yields insights into niche adaptation of plant
RT   vascular wilt pathogens.";
RL   PLoS Pathog. 7:E1002137-E1002137(2011).
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. Is also involved in ribosome biogenesis.
CC       Associates with pre-60S subunits in the nucleus and is involved in its
CC       nuclear export. {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- PTM: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EEY22623.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS985226; EEY22623.1; ALT_FRAME; Genomic_DNA.
DR   RefSeq; XP_003000937.1; XM_003000891.1.
DR   AlphaFoldDB; C9SV08; -.
DR   SMR; C9SV08; -.
DR   STRING; 526221.C9SV08; -.
DR   EnsemblFungi; EEY22623; EEY22623; VDBG_08733.
DR   GeneID; 9534325; -.
DR   KEGG; val:VDBG_08733; -.
DR   eggNOG; KOG3185; Eukaryota.
DR   HOGENOM; CLU_1365925_0_0_1; -.
DR   Proteomes; UP000008698; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Nucleus; Phosphoprotein;
KW   Protein biosynthesis; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..246
FT                   /note="Eukaryotic translation initiation factor 6"
FT                   /id="PRO_0000402112"
FT   MOD_RES         174
FT                   /note="Phosphoserine; by CK1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03132"
FT   MOD_RES         175
FT                   /note="Phosphoserine; by CK1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03132"
SQ   SEQUENCE   246 AA;  26577 MW;  4B5A0A5928125123 CRC64;
     MAVRAQFENS NEVGVFATLT NSYALTAIGA SENFYSVFEA ELQDVIPICR TTIAGSRIIG
     RMTAGNRKGL LVPTNTTDQE LQHLRNSLPD AIRIQRIEER LSALGNVIVT NDHIALVHPD
     IERETEEIIA DVLGVEVFRQ TIADNVLVGS YMSLSNQGGL VHPKTSIQDQ DELSSLLQVP
     LVAGSVNRGS NVVGAGMVVN DWMAVTGLDT TATELSVIES VFRLGEGLGP SNINTGMKDT
     MVESFY
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024