ID   IF6_XENLA               Reviewed;         245 AA.
AC   Q6GR45; Q6TXJ9;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};
GN   Name=eif6;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16425228; DOI=10.1002/mrd.20449;
RA   Vaccaro M.C., Cuccaro M., De Marco N., Campanella C.;
RT   "Expression of p27BBP/eIF6 is highly modulated during Xenopus laevis
RT   embryogenesis.";
RL   Mol. Reprod. Dev. 73:482-490(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03132}.
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DR   EMBL; AY383654; AAQ88443.1; -; mRNA.
DR   EMBL; BC071088; AAH71088.1; -; mRNA.
DR   RefSeq; NP_001083080.1; NM_001089611.1.
DR   AlphaFoldDB; Q6GR45; -.
DR   SMR; Q6GR45; -.
DR   iPTMnet; Q6GR45; -.
DR   DNASU; 398731; -.
DR   GeneID; 398731; -.
DR   KEGG; xla:398731; -.
DR   CTD; 398731; -.
DR   Xenbase; XB-GENE-868348; eif6.S.
DR   OrthoDB; 1157302at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 398731; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   PANTHER; PTHR10784; PTHR10784; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   TIGRFAMs; TIGR00323; eIF-6; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW   Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..245
FT                   /note="Eukaryotic translation initiation factor 6"
FT                   /id="PRO_0000402097"
FT   CONFLICT        238
FT                   /note="D -> G (in Ref. 1; AAQ88443)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   245 AA;  26654 MW;  22527055B5E0258A CRC64;
     MAVRASFENN NEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSETIPVVH ASIAGCRIIG
     RMCVGNRHGL MVPNNTTDQE LQHMRNSLPD SVRIQRVEER LSALGNVIAC NDYVALVHPD
     LDRETEEILA DVLKVEVFRQ TIAEQVLVGS YCAFSNQGGL LHPKTSIEDQ DELSSLLQVP
     LVTGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVIES VFKLSDAHPS TIATSMRDSL
     IDSLT