IFC1_CAEEL
ID IFC1_CAEEL Reviewed; 500 AA.
AC O45168; Q21066;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Intermediate filament protein ifc-1;
DE AltName: Full=Cel IF C1;
DE AltName: Full=Intermediate filament protein C1;
DE Short=IF-C1;
GN Name=ifc-1; ORFNames=F37B4.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=8013462; DOI=10.1002/j.1460-2075.1994.tb06553.x;
RA Dodemont H., Riemer D., Ledger T.N., Weber K.;
RT "Eight genes and alternative RNA processing pathways generate an
RT unexpectedly large diversity of cytoplasmic intermediate filament proteins
RT in the nematode Caenorhabditis elegans.";
RL EMBO J. 13:2625-2638(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION.
RX PubMed=11427699; DOI=10.1073/pnas.121169998;
RA Karabinos A., Schmidt H., Harborth J., Schnabel R., Weber K.;
RT "Essential roles for four cytoplasmic intermediate filament proteins in
RT Caenorhabditis elegans development.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7863-7868(2001).
CC -!- FUNCTION: Cytoplasmic intermediate filaments provide mechanical
CC strength to cells. Not essential protein.
CC {ECO:0000269|PubMed:11427699}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; X70832; CAA50180.1; -; Genomic_DNA.
DR EMBL; FO080739; CCD66314.1; -; Genomic_DNA.
DR PIR; S46328; S46328.
DR RefSeq; NP_503783.1; NM_071382.6.
DR AlphaFoldDB; O45168; -.
DR SMR; O45168; -.
DR BioGRID; 43804; 3.
DR STRING; 6239.F37B4.2; -.
DR iPTMnet; O45168; -.
DR EPD; O45168; -.
DR PaxDb; O45168; -.
DR PeptideAtlas; O45168; -.
DR EnsemblMetazoa; F37B4.2.1; F37B4.2.1; WBGene00002055.
DR GeneID; 178747; -.
DR KEGG; cel:CELE_F37B4.2; -.
DR UCSC; F37B4.2.1; c. elegans.
DR CTD; 178747; -.
DR WormBase; F37B4.2; CE27378; WBGene00002055; ifc-1.
DR eggNOG; KOG0977; Eukaryota.
DR GeneTree; ENSGT00970000196495; -.
DR HOGENOM; CLU_030212_0_0_1; -.
DR InParanoid; O45168; -.
DR OMA; THSRKMV; -.
DR OrthoDB; 701388at2759; -.
DR PhylomeDB; O45168; -.
DR PRO; PR:O45168; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00002055; Expressed in larva and 2 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0005652; C:nuclear lamina; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0031507; P:heterochromatin assembly; IBA:GO_Central.
DR GO; GO:0006998; P:nuclear envelope organization; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR GO; GO:0051664; P:nuclear pore localization; IBA:GO_Central.
DR GO; GO:0090435; P:protein localization to nuclear envelope; IBA:GO_Central.
DR InterPro; IPR039008; IF_rod_dom.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Intermediate filament; Reference proteome.
FT CHAIN 1..500
FT /note="Intermediate filament protein ifc-1"
FT /id="PRO_0000063840"
FT DOMAIN 33..383
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..36
FT /note="Head"
FT REGION 37..68
FT /note="Coil 1A"
FT REGION 69..81
FT /note="Linker 1"
FT REGION 82..219
FT /note="Coil 1B"
FT REGION 220..237
FT /note="Linker 12"
FT REGION 238..383
FT /note="Coil 2"
FT REGION 384..496
FT /note="Tail"
SQ SEQUENCE 500 AA; 55868 MW; 4A32B8F1052F1F01 CRC64;
MSLYGGIPTN LVSGMSSAGA ICTTQIRDAR EREKREIGLL NDRLADYIEK VRFLKAQNHV
LSHDIEILRR GFSGGGHISS FFESEISNCT VISERILSSR TKFQADITGL EGEIEIYRKK
WLEALKVVRS HREDHHVNLD KLAEVEAQIA LFNRKIRIVE EDVLRIRRET GGIQNDIGRI
HSQIHAEIAL KNERHHSVQM LLQRVQVIQT ENSSRIEQEL IYIHRDTTLE NRDYFRQELQ
AAMRDIRANY EAMSIRSRED IEIAYRKRID EIRVIPAHVH IEDYREELLS IRTTLSTTHS
RLAEIESRNA WLLTTITDLK HQQAEEARIF EATLDAKQAT YEQFKERCTE LSIQMEKLCD
HETSLQAELE RYRVLLNGAN VTTYVSNSTG AAGYRSSTHV ATTTTTTTNG YSSGYTAGGY
TSGGYTTGGY TRGITAGGAV GGISTGGYIG RSSSSHGISV GGNIGGVSVG GHINGYHASG
DISAAGRHHE SSYSYSSSNN
