ID   IFC2_CAEBR              Reviewed;         621 AA.
AC   Q5WN60; A8X5W5;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Intermediate filament protein ifc-2;
GN   Name=ifc-2 {ECO:0000250|UniProtKB:Q21067}; ORFNames=CBG08136;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Cytoplasmic intermediate filaments provide mechanical
CC       strength to cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP28026.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE600971; CAP28026.2; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q5WN60; -.
DR   SMR; Q5WN60; -.
DR   STRING; 6238.CBG08136; -.
DR   WormBase; CBG08136a; CBP44364; WBGene00029993; Cbr-ifc-2.
DR   eggNOG; KOG0977; Eukaryota.
DR   HOGENOM; CLU_279425_0_0_1; -.
DR   InParanoid; Q5WN60; -.
DR   OrthoDB; 701388at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0005652; C:nuclear lamina; IBA:GO_Central.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR   GO; GO:0031507; P:heterochromatin assembly; IBA:GO_Central.
DR   GO; GO:0006998; P:nuclear envelope organization; IBA:GO_Central.
DR   GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR   GO; GO:0051664; P:nuclear pore localization; IBA:GO_Central.
DR   GO; GO:0090435; P:protein localization to nuclear envelope; IBA:GO_Central.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR001322; Lamin_tail_dom.
DR   InterPro; IPR036415; Lamin_tail_dom_sf.
DR   Pfam; PF00038; Filament; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF74853; SSF74853; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   PROSITE; PS51841; LTD; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Intermediate filament; Reference proteome.
FT   CHAIN           1..621
FT                   /note="Intermediate filament protein ifc-2"
FT                   /id="PRO_0000063841"
FT   DOMAIN          52..400
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   DOMAIN          508..621
FT                   /note="LTD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT   REGION          20..55
FT                   /note="Head"
FT   REGION          56..87
FT                   /note="Coil 1A"
FT   REGION          88..100
FT                   /note="Linker 1"
FT   REGION          101..238
FT                   /note="Coil 1B"
FT   REGION          239..256
FT                   /note="Linker 12"
FT   REGION          257..400
FT                   /note="Coil 2"
FT   REGION          401..549
FT                   /note="Tail"
SQ   SEQUENCE   621 AA;  69510 MW;  5AFAFFA246FD2FB8 CRC64;
     MSTYGYTHYT STSQGRGLAS GAYTSGFGGL VSGMSSAGAI CTTQIRDARE REKREIGLLN
     DRLADYIEKV RFLEAQNQCL SHDIDILRRG FSGGGHVSGL YDTEIAQAKR ILEQTIAGHA
     AFDRDIAALG SDIDAIRKKW IDAVNAVKAH REDHDVDLDR LAKVEAEISL FKRKIRIVEE
     DVIRIRREND GIYNEIARIK QLTHNEIALK NERSLNVQDL LQRIKLLQTE NSTRIEQELV
     FIRRDTTAEN RDYFRHELQA AIRDIRADYE AISIRNRNDI EVWYREQIRK IQTESKPVNQ
     DLYKEELASI RTTVTNVKSR LAEVEGRNFF LEKLIEDLRN NEESKLYEIS LAEKDAQIAR
     LREQCTELSI QMERLCDNEI SLRAEIERYR VLLNGANVTT YVSNTHPSGV SVGGIVGTTR
     VISQTTRTNS SSNTSYSGVP ASRTGYSVGG NIGGISVGGT IGGVSVGGNV GAHGASGHVS
     GGAAGSVSSL VSEKRPDRVH DEKGVDASGR SFHSWYLGTI SINQITPSYI ELKNICKIRR
     VDVGGFRVEQ YINGELLGSA QINVPLILDP QEVVRIHHRH GKYLGQFFMD VDAFDNSTAS
     RTSMYNYTEP NEERAWFVYL N