IFC2_CAEEL
ID IFC2_CAEEL Reviewed; 622 AA.
AC Q21067; O02366; Q21579; Q21580;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Intermediate filament protein ifc-2;
DE AltName: Full=Cel IF C2;
DE AltName: Full=Intermediate filament protein C2;
DE Short=IF-C2;
GN Name=ifc-2; ORFNames=M6.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING (ISOFORMS A AND
RP B).
RC STRAIN=Bristol N2;
RX PubMed=8013462; DOI=10.1002/j.1460-2075.1994.tb06553.x;
RA Dodemont H., Riemer D., Ledger T.N., Weber K.;
RT "Eight genes and alternative RNA processing pathways generate an
RT unexpectedly large diversity of cytoplasmic intermediate filament proteins
RT in the nematode Caenorhabditis elegans.";
RL EMBO J. 13:2625-2638(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=11427699; DOI=10.1073/pnas.121169998;
RA Karabinos A., Schmidt H., Harborth J., Schnabel R., Weber K.;
RT "Essential roles for four cytoplasmic intermediate filament proteins in
RT Caenorhabditis elegans development.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7863-7868(2001).
RN [4]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=12204276; DOI=10.1016/s0925-4773(02)00192-2;
RA Karabinos A., Schulze E., Klisch T., Wang J., Weber K.;
RT "Expression profiles of the essential intermediate filament (IF) protein A2
RT and the IF protein C2 in the nematode Caenorhabditis elegans.";
RL Mech. Dev. 117:311-314(2002).
CC -!- FUNCTION: Cytoplasmic intermediate filaments provide mechanical
CC strength to cells. Not essential protein, although its absence leads to
CC mild defects in locomotion. {ECO:0000269|PubMed:11427699}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12204276}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q21067-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q21067-2; Sequence=VSP_010149, VSP_010150;
CC -!- TISSUE SPECIFICITY: Expressed in intestinal cells and at desmosomes in
CC intestine and pharynx of the larva. {ECO:0000269|PubMed:12204276}.
CC -!- DEVELOPMENTAL STAGE: Expressed from late embryogenesis, and thereafter.
CC {ECO:0000269|PubMed:12204276}.
CC -!- DISRUPTION PHENOTYPE: Mutants exhibit mild dumpy phenotype and moderate
CC defects in movement in adults. {ECO:0000269|PubMed:11427699}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA50184.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CCD69439.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CCD69440.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X70836; CAA50184.1; ALT_SEQ; Genomic_DNA.
DR EMBL; FO081140; CCD69439.1; ALT_SEQ; Genomic_DNA.
DR EMBL; FO081140; CCD69440.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_001256975.1; NM_001270046.1. [Q21067-1]
DR RefSeq; NP_741705.1; NM_171613.5.
DR RefSeq; NP_741706.1; NM_171614.3.
DR AlphaFoldDB; Q21067; -.
DR SMR; Q21067; -.
DR BioGRID; 45367; 9.
DR DIP; DIP-24946N; -.
DR IntAct; Q21067; 2.
DR MINT; Q21067; -.
DR STRING; 6239.M6.1b; -.
DR World-2DPAGE; 0011:Q21067; -.
DR EPD; Q21067; -.
DR PaxDb; Q21067; -.
DR PeptideAtlas; Q21067; -.
DR EnsemblMetazoa; M6.1a.1; M6.1a.1; WBGene00002056.
DR EnsemblMetazoa; M6.1a.2; M6.1a.2; WBGene00002056.
DR EnsemblMetazoa; M6.1b.1; M6.1b.1; WBGene00002056.
DR GeneID; 180414; -.
DR UCSC; M6.1b; c. elegans. [Q21067-1]
DR CTD; 180414; -.
DR WormBase; M6.1a; CE31204; WBGene00002056; ifc-2.
DR WormBase; M6.1b; CE31205; WBGene00002056; ifc-2.
DR eggNOG; KOG0977; Eukaryota.
DR GeneTree; ENSGT00970000196495; -.
DR HOGENOM; CLU_030212_0_0_1; -.
DR InParanoid; Q21067; -.
DR OrthoDB; 701388at2759; -.
DR PhylomeDB; Q21067; -.
DR SignaLink; Q21067; -.
DR PRO; PR:Q21067; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00002056; Expressed in larva and 4 other tissues.
DR ExpressionAtlas; Q21067; baseline and differential.
DR GO; GO:0030054; C:cell junction; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0030057; C:desmosome; IDA:WormBase.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0005652; C:nuclear lamina; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0031507; P:heterochromatin assembly; IBA:GO_Central.
DR GO; GO:0006998; P:nuclear envelope organization; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR GO; GO:0051664; P:nuclear pore localization; IBA:GO_Central.
DR GO; GO:0048621; P:post-embryonic digestive tract morphogenesis; IMP:UniProtKB.
DR GO; GO:0090435; P:protein localization to nuclear envelope; IBA:GO_Central.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF74853; SSF74853; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Cytoplasm; Intermediate filament;
KW Reference proteome.
FT CHAIN 1..622
FT /note="Intermediate filament protein ifc-2"
FT /id="PRO_0000063842"
FT DOMAIN 51..399
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT DOMAIN 509..622
FT /note="LTD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT REGION 19..54
FT /note="Head"
FT REGION 55..86
FT /note="Coil 1A"
FT REGION 87..99
FT /note="Linker 1"
FT REGION 100..237
FT /note="Coil 1B"
FT REGION 238..255
FT /note="Linker 12"
FT REGION 256..399
FT /note="Coil 2"
FT REGION 400..550
FT /note="Tail"
FT VAR_SEQ 488..502
FT /note="VSSLITDKPRDRVHD -> GTYQQSHHSYSSSNH (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_010149"
FT VAR_SEQ 503..622
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_010150"
SQ SEQUENCE 622 AA; 70101 MW; 2C60BF55FE97729E CRC64;
MSTYAAYTTS TYQGRGLASG TYASGFGQLV SGMSSAGAIC TTQIRDARER EKREIGLLND
RLADYIEKVR FLEAQNRCLS HDIDILRNGF SGGGHVSGLF DAEINQAKHI LEQTTAHRST
FERDITGLSA EIEVFRKKWL DAVNAVKAHR EDHDVDLDRL AKIEAEISLF KRKIRIVEED
VIRIRRENDG IYNEIARIKQ LTHNEIALKN ERSLNVSDLL QRINLLQTEN NVRIEQELVF
IRRDTTADNR DYFRHELQAA IRDIRADYEA ISIRNRQDIE VWYREQIRKI QDESVRVNPD
LYKEELISIR TTVTNVRSRL AEVEGRNFFL ERLIDDLKNN EEAKFFEISL AERDAQIATL
RDQCTELSIQ MEKLCDNEIS LRAEIERYRI LLNGANVTTY TSNTHGSGSG IAVGGVVGGS
TRVISQTTRT HSSSNTSYSN VPASRGGYSI SGNVGGISVG GTIGSHGASA HATGGIIGSG
VQAHRGSVSS LITDKPRDRV HDEKGVDQSG RHFHSWYLGT ISINQVTPSY IELKNICKIR
RVDVGGFRIE QSVNGQVLGS AQINVPLILD PQEVVRFNHR HGKYLGQFFM DVDAFDNSTV
ARTSMYNYTE PHEERAWFVY LD
