IFD1_CAEEL
ID IFD1_CAEEL Reviewed; 575 AA.
AC Q86DC6; Q9GYL1;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Intermediate filament protein ifd-1;
DE AltName: Full=Cel IF D1;
DE AltName: Full=Intermediate filament protein D1;
DE Short=IF-D1;
GN Name=ifd-1; ORFNames=R04E5.10;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=11427699; DOI=10.1073/pnas.121169998;
RA Karabinos A., Schmidt H., Harborth J., Schnabel R., Weber K.;
RT "Essential roles for four cytoplasmic intermediate filament proteins in
RT Caenorhabditis elegans development.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7863-7868(2001).
CC -!- FUNCTION: Cytoplasmic intermediate filaments provide mechanical
CC strength to cells. Not essential protein.
CC {ECO:0000269|PubMed:11427699}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q86DC6-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q86DC6-2; Sequence=VSP_010151, VSP_010152;
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080702; CCD65958.1; -; Genomic_DNA.
DR EMBL; FO080702; CCD65959.1; -; Genomic_DNA.
DR RefSeq; NP_001024830.1; NM_001029659.4. [Q86DC6-1]
DR RefSeq; NP_001024831.1; NM_001029660.3.
DR AlphaFoldDB; Q86DC6; -.
DR SMR; Q86DC6; -.
DR BioGRID; 52274; 5.
DR DIP; DIP-26000N; -.
DR IntAct; Q86DC6; 2.
DR STRING; 6239.R04E5.10a; -.
DR iPTMnet; Q86DC6; -.
DR EPD; Q86DC6; -.
DR PaxDb; Q86DC6; -.
DR PeptideAtlas; Q86DC6; -.
DR PRIDE; Q86DC6; -.
DR EnsemblMetazoa; R04E5.10.1; R04E5.10.1; WBGene00002057. [Q86DC6-1]
DR GeneID; 187585; -.
DR KEGG; cel:CELE_R04E5.10; -.
DR UCSC; R04E5.10a; c. elegans. [Q86DC6-1]
DR CTD; 187585; -.
DR WormBase; R04E5.10a; CE30100; WBGene00002057; ifd-1. [Q86DC6-1]
DR WormBase; R04E5.10b; CE33933; WBGene00002057; ifd-1. [Q86DC6-2]
DR eggNOG; KOG0977; Eukaryota.
DR GeneTree; ENSGT00970000196250; -.
DR HOGENOM; CLU_032944_0_0_1; -.
DR InParanoid; Q86DC6; -.
DR OMA; WEEWYKK; -.
DR OrthoDB; 701388at2759; -.
DR PhylomeDB; Q86DC6; -.
DR SignaLink; Q86DC6; -.
DR PRO; PR:Q86DC6; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00002057; Expressed in larva and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0005652; C:nuclear lamina; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0031507; P:heterochromatin assembly; IBA:GO_Central.
DR GO; GO:0006998; P:nuclear envelope organization; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR GO; GO:0051664; P:nuclear pore localization; IBA:GO_Central.
DR GO; GO:0090435; P:protein localization to nuclear envelope; IBA:GO_Central.
DR Gene3D; 2.60.40.1260; -; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF74853; SSF74853; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Coiled coil; Cytoplasm; Intermediate filament;
KW Reference proteome.
FT CHAIN 1..575
FT /note="Intermediate filament protein ifd-1"
FT /id="PRO_0000063843"
FT DOMAIN 53..406
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT DOMAIN 459..575
FT /note="LTD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT REGION 1..56
FT /note="Head"
FT REGION 57..88
FT /note="Coil 1A"
FT REGION 89..102
FT /note="Linker 1"
FT REGION 103..240
FT /note="Coil 1B"
FT REGION 241..258
FT /note="Linker 12"
FT REGION 259..408
FT /note="Coil 2"
FT REGION 409..572
FT /note="Tail"
FT VAR_SEQ 442..465
FT /note="NKTVHHDNYDISSASTINTQQFRS -> KIPPCWYIFGRKVKFGIFRPVKPK
FT (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_010151"
FT VAR_SEQ 466..575
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_010152"
SQ SEQUENCE 575 AA; 66700 MW; DCD9581BECC52C01 CRC64;
MSKLNPRVAH NPVLSRIIES GRTNLPSGIT SAGSLSAYAQ AAAVTIRDNR DREKREIADL
NNRLARYVEK VRFLEAQNRV LENDIGLFRQ AAHIHTGKVR DYYDAEKTSL ATLVREQEAK
VSSAKQNIRK LEPEITTAIR TLASSLEHRQ RVRSDKKEQL KHLSDLESET AYIKRLINDC
DDEKSHLKTE ISRIRGEIKR ILALRDKERN GFSRSQTAAQ DLLKKLNATI STHEIAIREE
INKARRDSTD KNREFFHREL HMSMKEIRDQ FESDSKKARK TWEEWYKKKI TEIKKRSEKF
SLTQNQAREE VLRIRSLLNE LRTKISDADS MTQALSKRIE DMKFREDEEL RMFEQSLTEK
ELAVTRMRDE CAKLSVELET LVENQINLRS EIAHYRKLME QAENLRTSYQ SDFVIDTPSP
LMRTSSHHYG SSYSLNVRDT HNKTVHHDNY DISSASTINT QQFRSYGKGD VKIIEHKDES
IVIENSNSYK SKDLSNWKIN HYVNGALTGT FILPVATHIH PHEKISIHSL KSPNLMDDIV
ATQIYSFDFS KNTKTVLLDD VDDEVGWYAH VSYSH
