IFD2_CAEEL
ID IFD2_CAEEL Reviewed; 443 AA.
AC Q19782;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Intermediate filament protein ifd-2;
DE AltName: Full=Cel IF D2;
DE AltName: Full=Intermediate filament protein D2;
DE Short=IF-D2;
GN Name=ifd-2; ORFNames=F25E2.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=11427699; DOI=10.1073/pnas.121169998;
RA Karabinos A., Schmidt H., Harborth J., Schnabel R., Weber K.;
RT "Essential roles for four cytoplasmic intermediate filament proteins in
RT Caenorhabditis elegans development.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7863-7868(2001).
CC -!- FUNCTION: Cytoplasmic intermediate filaments provide mechanical
CC strength to cells. Not essential protein.
CC {ECO:0000269|PubMed:11427699}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; FO081218; CCD69985.1; -; Genomic_DNA.
DR PIR; T29820; T29820.
DR RefSeq; NP_508160.1; NM_075759.4.
DR AlphaFoldDB; Q19782; -.
DR SMR; Q19782; -.
DR BioGRID; 45383; 6.
DR DIP; DIP-24353N; -.
DR IntAct; Q19782; 3.
DR STRING; 6239.F25E2.4; -.
DR EPD; Q19782; -.
DR PaxDb; Q19782; -.
DR PeptideAtlas; Q19782; -.
DR PRIDE; Q19782; -.
DR EnsemblMetazoa; F25E2.4.1; F25E2.4.1; WBGene00002058.
DR GeneID; 180430; -.
DR KEGG; cel:CELE_F25E2.4; -.
DR UCSC; F25E2.4; c. elegans.
DR CTD; 180430; -.
DR WormBase; F25E2.4; CE07133; WBGene00002058; ifd-2.
DR eggNOG; KOG0977; Eukaryota.
DR GeneTree; ENSGT00970000196250; -.
DR HOGENOM; CLU_032944_0_0_1; -.
DR InParanoid; Q19782; -.
DR OMA; KMREECT; -.
DR OrthoDB; 701388at2759; -.
DR PhylomeDB; Q19782; -.
DR PRO; PR:Q19782; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00002058; Expressed in material anatomical entity and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0005652; C:nuclear lamina; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0031507; P:heterochromatin assembly; IBA:GO_Central.
DR GO; GO:0006998; P:nuclear envelope organization; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR GO; GO:0051664; P:nuclear pore localization; IBA:GO_Central.
DR GO; GO:0090435; P:protein localization to nuclear envelope; IBA:GO_Central.
DR InterPro; IPR039008; IF_rod_dom.
DR Pfam; PF00038; Filament; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Intermediate filament; Reference proteome.
FT CHAIN 1..443
FT /note="Intermediate filament protein ifd-2"
FT /id="PRO_0000063844"
FT DOMAIN 55..405
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..58
FT /note="Head"
FT REGION 59..90
FT /note="Coil 1A"
FT REGION 91..104
FT /note="Linker 1"
FT REGION 105..239
FT /note="Coil 1B"
FT REGION 240..257
FT /note="Linker 12"
FT REGION 258..403
FT /note="Coil 2"
FT REGION 404..443
FT /note="Tail"
SQ SEQUENCE 443 AA; 51581 MW; 2B6A54DDCB17730B CRC64;
MTDPLNPTRL QNHPALARII ESGRTNLPTG ITTSGALSAY AQNAAAIIRD NREREKVEIA
DLNNRLARYV EKVRFLEAQN RVLENDIGVF RNAAHTHSER IAVYFESEKA SLFTLVRENK
AKISTAEQNI RKLEPDVISA KKNLESSFQL RVQTREDKRS QMKILSNLEA ENSYIKRLTT
DCEEEKSRVH SEISRLRSDI KRVHALRDKE RSKHSSSSQE LLKRLNGCIS QHDIAIREEI
SKARRDTTNK NRDYFHNELH AAMKEIRDRF EKDSRAARKT WEDWYHKKIT EIKKGSESYS
SIQNQAREEI LRIRSIVNEF RGKLSDSETI NQQLIKRIDD LHFQDKENLR LFEIALNEKE
NLVIKMREEC TKLSVELDKL VENQINLRNE INHYRKLMEN AEHLRTTVQT HVTYNAPPPP
LPQSGPRTTS YHAYGSAYND SLL
