ID   IFEA_ASCSU              Reviewed;         497 AA.
AC   P23730;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Intermediate filament protein A;
DE            Short=IF-A;
DE   Flags: Fragment;
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2583097; DOI=10.1002/j.1460-2075.1989.tb08481.x;
RA   Weber K., Plessmann U., Ulrich W.;
RT   "Cytoplasmic intermediate filament proteins of invertebrates are closer to
RT   nuclear lamins than are vertebrate intermediate filament proteins; sequence
RT   characterization of two muscle proteins of a nematode.";
RL   EMBO J. 8:3221-3227(1989).
CC   -!- SUBUNIT: A and B can form homopolymers.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Giant body muscle cells.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   AlphaFoldDB; P23730; -.
DR   SMR; P23730; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005882; C:intermediate filament; IDA:CACAO.
DR   Gene3D; 2.60.40.1260; -; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR016451; Intermed_filament_ifa/ifb.
DR   InterPro; IPR001322; Lamin_tail_dom.
DR   InterPro; IPR036415; Lamin_tail_dom_sf.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF00932; LTD; 1.
DR   PIRSF; PIRSF005546; Intermed_filamnt_Ifb-2; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF74853; SSF74853; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   PROSITE; PS51841; LTD; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Direct protein sequencing; Intermediate filament.
FT   CHAIN           <1..497
FT                   /note="Intermediate filament protein A"
FT                   /id="PRO_0000063832"
FT   DOMAIN          <1..342
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   DOMAIN          375..493
FT                   /note="LTD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT   REGION          1..32
FT                   /note="Coil 1A"
FT   REGION          33..46
FT                   /note="Linker 1"
FT   REGION          47..184
FT                   /note="Coil 1B"
FT   REGION          185..202
FT                   /note="Linker 12"
FT   REGION          203..342
FT                   /note="Coil 2"
FT   REGION          343..497
FT                   /note="Tail"
FT   NON_TER         1
SQ   SEQUENCE   497 AA;  58138 MW;  133C72874975235E CRC64;
     MSDLNDRLAS YIEKVRFLEA QNRKLAADLD LLRGRWGKDT LSVRAMYEGE LQEARKLVND
     TNRQREELEK EIRKLLDELS EYRRKYEDAL RGHQIDRDRI DELLNQLSGL EAEINLLRRR
     IANIIEEIAR IKKENLQFAN ELTKARSDLD QETLNRIDFQ NQVQTLLEEI DFMRRVHDQE
     IAELQAMASR DTTPENREYF KNELASAIRD IRAEYDQICN VNRMDMESWY KLKVQEIQTQ
     STRQNLEQNY AKKRLRVQLT DLRGKLADLE GRNSLLKQTQ ELNYQLEDDQ RSYEAALNDR
     DAQIRKMDEE CQALMMLLDT KQTLDAEIAI YRKMLEGEEN RAGLRQLVEQ VVKTHGLTQV
     DETESLRVLK GETASRTSFQ RSAKGNVSIQ ETAPDGRYVV LENTHRSKEE AIGEWKLKRK
     IDGKREIVYT LPRDFILRPG KSVKIWARGQ GGIHSPPEQL VFDLEDTFGS GSNVQTILFN
     REGEERATHI QRSSHTI