ID   IFEA_CORAP              Reviewed;         576 AA.
AC   P22488; P22489;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Non-neuronal cytoplasmic intermediate filament protein;
DE            Short=IF;
OS   Cornu aspersum (Brown garden snail) (Helix aspersa).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata; Stylommatophora;
OC   Helicina; Helicoidea; Helicidae; Cornu; Cornu.
OX   NCBI_TaxID=6535;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B).
RC   TISSUE=Esophageal epithelium;
RX   PubMed=2249666; DOI=10.1002/j.1460-2075.1990.tb07630.x;
RA   Dodemont H., Riemer D., Weber K.;
RT   "Structure of an invertebrate gene encoding cytoplasmic intermediate
RT   filament (IF) proteins: implications for the origin and the diversification
RT   of IF proteins.";
RL   EMBO J. 9:4083-4094(1990).
CC   -!- SUBUNIT: Can form homopolymers.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A;
CC         IsoId=P22488-1; Sequence=Displayed;
CC       Name=B;
CC         IsoId=P22488-2; Sequence=VSP_002474, VSP_002475;
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; X55947; CAA39416.1; -; Genomic_DNA.
DR   EMBL; X55947; CAA39415.1; -; Genomic_DNA.
DR   PIR; S12277; S12277.
DR   AlphaFoldDB; P22488; -.
DR   SMR; P22488; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1260; -; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR016451; Intermed_filament_ifa/ifb.
DR   InterPro; IPR001322; Lamin_tail_dom.
DR   InterPro; IPR036415; Lamin_tail_dom_sf.
DR   Pfam; PF00038; Filament; 1.
DR   PIRSF; PIRSF005546; Intermed_filamnt_Ifb-2; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF74853; SSF74853; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   PROSITE; PS51841; LTD; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Coiled coil; Cytoplasm; Intermediate filament.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..576
FT                   /note="Non-neuronal cytoplasmic intermediate filament
FT                   protein"
FT                   /id="PRO_0000063829"
FT   DOMAIN          73..425
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   DOMAIN          456..574
FT                   /note="LTD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2..75
FT                   /note="Head"
FT   REGION          76..108
FT                   /note="Coil 1A"
FT   REGION          109..122
FT                   /note="Linker 1"
FT   REGION          123..260
FT                   /note="Coil 1B"
FT   REGION          261..278
FT                   /note="Linker 2"
FT   REGION          279..425
FT                   /note="Coil 2"
FT   REGION          426..576
FT                   /note="Tail"
FT   COMPBIAS        21..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         453
FT                   /note="T -> S (in isoform B)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_002474"
FT   VAR_SEQ         454..576
FT                   /note="Missing (in isoform B)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_002475"
SQ   SEQUENCE   576 AA;  64479 MW;  CE6A41B0B9B0819E CRC64;
     MTSKISTTYE EEGRQSKIQP RAFVITRSGP SSKSSSFSAR QSYASSRQSI TPGVYQQLSS
     SGITDFRGTR EKEKREMQNL NERLASYIEK VHFLDAQVKK LEAENEALRN RKSESLQPIR
     DAYENELAQA RKVIDELSST KGVSEAKVAG LQDEIASLRE LIVTYENQSK DYRKKIESLG
     NQIGEYEGEL HTLRIRCGSL EDENAKVREL LDKIQEQNRR LRADLDTETA AHIEADCLAQ
     TKTEEAEFYK DLLDQLELLK PEPIQIKGMD YAEFWKSELS KCVREIQSAY DEKIDMIQQD
     TEAKYSAQLN SLRSGNVKDG MQLQHVQEEV KKLRTQAGEK NAMYAELAAK FASLQAERDS
     IGRQCSELER ELEELRIKYN QDIGDLSNEL SAVLAQLQIL TDAKITMELE IACYRKLLEG
     EESRVGLRSL VEQAIGVQGR GTASLKDTIQ QSTSSGSMTI QRSSKGPIAF NSVDQSGSNI
     VIENTTSGAR AKTQSLRGWR IDKTVAGRVA ASIQLKDYEI PPNTKYTIWA KGAKDRATAD
     NEQIADIFSL GVGSCTWTIV DEAGNEKATL IAKFSG