IFEA_HELPO
ID IFEA_HELPO Reviewed; 551 AA.
AC P16274;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 29-SEP-2021, entry version 97.
DE RecName: Full=Non-neuronal cytoplasmic intermediate filament protein A;
DE Short=IFA;
DE Flags: Fragments;
OS Helix pomatia (Roman snail) (Edible snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata; Stylommatophora;
OC Helicina; Helicoidea; Helicidae; Helix.
OX NCBI_TaxID=6536;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Esophageal epithelium;
RX PubMed=3181126; DOI=10.1002/j.1460-2075.1988.tb03162.x;
RA Weber K., Plessmann U., Dodemont H., Kossmagk-Stephan K.;
RT "Amino acid sequences and homopolymer-forming ability of the intermediate
RT filament proteins from an invertebrate epithelium.";
RL EMBO J. 7:2995-3001(1988).
CC -!- FUNCTION: Epithelial intermediate filament protein.
CC -!- SUBUNIT: Can form homomers.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=IFA;
CC IsoId=P16274-1; Sequence=Displayed;
CC Name=IFB;
CC IsoId=P16275-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR PIR; S01295; S01295.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IDA:CACAO.
DR Gene3D; 2.60.40.1260; -; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR SUPFAM; SSF74853; SSF74853; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Coiled coil; Cytoplasm;
KW Direct protein sequencing; Intermediate filament.
FT CHAIN 1..551
FT /note="Non-neuronal cytoplasmic intermediate filament
FT protein A"
FT /id="PRO_0000063830"
FT DOMAIN 71..423
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT DOMAIN 454..551
FT /note="LTD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT REGION 1..74
FT /note="Head"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..106
FT /note="Coil 1A"
FT REGION 107..120
FT /note="Linker 1"
FT REGION 121..258
FT /note="Coil 1B"
FT REGION 259..275
FT /note="Linker 12"
FT REGION 276..423
FT /note="Coil 2"
FT REGION 424..551
FT /note="Tail"
FT COMPBIAS 20..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000250|UniProtKB:P16275"
SQ SEQUENCE 551 AA; 61235 MW; 116C48B6DAA8A0F9 CRC64;
TSKISTTYEE EGRQSKIQPR AFVITRSGPT SRSSSYSARQ SYGSRSSITP GVYQQLSSSG
ITDFRGTREK EKREMQNLNE RLAGYIEKVH FLDAQVKKLE AENXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXMDYA EFWKSELSKC VRDIQSAYDE KIDIIXXXXX
XXXXXXXXXX XXXXXXXXMQ LQHVQEEVKK LRTQAGEKNA AYAEXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXMELEIA CYRKLLEGEE
SRVGLRSLVE QAIGVQGRGT ASLKDTIQQS TASGSMTVQR SSKGPIAFNS VDQSGSNIVI
ENTTSGARAK TQSLKGWRVD KTVAGRVAAS IELKNYDLPP NTKYTIWAKG AKDRATADNE
QIADMFSLGV G
