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IFEB_HELPO
ID   IFEB_HELPO              Reviewed;         450 AA.
AC   P16275;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Non-neuronal cytoplasmic intermediate filament protein B;
DE            Short=IFB;
OS   Helix pomatia (Roman snail) (Edible snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata; Stylommatophora;
OC   Helicina; Helicoidea; Helicidae; Helix.
OX   NCBI_TaxID=6536;
RN   [1]
RP   PROTEIN SEQUENCE, AND ACETYLATION AT THR-1.
RC   TISSUE=Esophageal epithelium;
RX   PubMed=3181126; DOI=10.1002/j.1460-2075.1988.tb03162.x;
RA   Weber K., Plessmann U., Dodemont H., Kossmagk-Stephan K.;
RT   "Amino acid sequences and homopolymer-forming ability of the intermediate
RT   filament proteins from an invertebrate epithelium.";
RL   EMBO J. 7:2995-3001(1988).
CC   -!- FUNCTION: Epithelial intermediate filament protein.
CC   -!- SUBUNIT: Can form homomers.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=IFB;
CC         IsoId=P16275-1; Sequence=Displayed;
CC       Name=IFA;
CC         IsoId=P16274-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   PIR; S01294; S01294.
DR   AlphaFoldDB; P16275; -.
DR   SMR; P16275; -.
DR   iPTMnet; P16275; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005882; C:intermediate filament; IDA:CACAO.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   Pfam; PF00038; Filament; 1.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Alternative splicing; Coiled coil; Cytoplasm;
KW   Direct protein sequencing; Intermediate filament.
FT   CHAIN           1..450
FT                   /note="Non-neuronal cytoplasmic intermediate filament
FT                   protein B"
FT                   /id="PRO_0000063831"
FT   DOMAIN          71..423
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..74
FT                   /note="Head"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          75..106
FT                   /note="Coil 1A"
FT   REGION          107..120
FT                   /note="Linker 1"
FT   REGION          121..258
FT                   /note="Coil 1B"
FT   REGION          259..275
FT                   /note="Linker 12"
FT   REGION          276..423
FT                   /note="Coil 2"
FT   REGION          424..450
FT                   /note="Tail"
FT   COMPBIAS        20..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0000269|PubMed:3181126"
SQ   SEQUENCE   450 AA;  51000 MW;  75C081960A490015 CRC64;
     TSKISTTYEE EGRQSKIQPR AFVITRSGPT SRSSSYSARQ SYGSRSSITP GVYQQLSSSG
     ITDFRGTREK EKREMQNLNE RLAGYIEKVH FLDAQVKKLE AENEALRNRK SESLQPIRDA
     YENELAQARK VIDELSSTKG VSEAKVAGLQ DEIASLRELI GTYENQSKDY RKKIESLGNQ
     IGEYEGELHT LRIRCGSLED ENAKVRELLD KIQDQNRRLR ADLDTETSAH IEADCLAQTK
     TEECEFYKDL LDQLELLKPE PMQIKGMDYA EFWKSELSKC VRDIQSAYDE KIDIIQQDIE
     AKYSSQINSL RSGNVKDGMQ LQHVQEEVKK LRTQAGEKNA AYAELAAKFA SLQAERDAIG
     RQCSELEREL EELRIKYNQD IGDLSNELSA VLAQLQTLTD VKITMELEIA CYRKLLEGEE
     SRVGLRSLVE QAIGVQGRGT ASLKDTIQQS
 
 
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