IFEB_HELPO
ID IFEB_HELPO Reviewed; 450 AA.
AC P16275;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Non-neuronal cytoplasmic intermediate filament protein B;
DE Short=IFB;
OS Helix pomatia (Roman snail) (Edible snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata; Stylommatophora;
OC Helicina; Helicoidea; Helicidae; Helix.
OX NCBI_TaxID=6536;
RN [1]
RP PROTEIN SEQUENCE, AND ACETYLATION AT THR-1.
RC TISSUE=Esophageal epithelium;
RX PubMed=3181126; DOI=10.1002/j.1460-2075.1988.tb03162.x;
RA Weber K., Plessmann U., Dodemont H., Kossmagk-Stephan K.;
RT "Amino acid sequences and homopolymer-forming ability of the intermediate
RT filament proteins from an invertebrate epithelium.";
RL EMBO J. 7:2995-3001(1988).
CC -!- FUNCTION: Epithelial intermediate filament protein.
CC -!- SUBUNIT: Can form homomers.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=IFB;
CC IsoId=P16275-1; Sequence=Displayed;
CC Name=IFA;
CC IsoId=P16274-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR PIR; S01294; S01294.
DR AlphaFoldDB; P16275; -.
DR SMR; P16275; -.
DR iPTMnet; P16275; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IDA:CACAO.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Coiled coil; Cytoplasm;
KW Direct protein sequencing; Intermediate filament.
FT CHAIN 1..450
FT /note="Non-neuronal cytoplasmic intermediate filament
FT protein B"
FT /id="PRO_0000063831"
FT DOMAIN 71..423
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..74
FT /note="Head"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..106
FT /note="Coil 1A"
FT REGION 107..120
FT /note="Linker 1"
FT REGION 121..258
FT /note="Coil 1B"
FT REGION 259..275
FT /note="Linker 12"
FT REGION 276..423
FT /note="Coil 2"
FT REGION 424..450
FT /note="Tail"
FT COMPBIAS 20..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000269|PubMed:3181126"
SQ SEQUENCE 450 AA; 51000 MW; 75C081960A490015 CRC64;
TSKISTTYEE EGRQSKIQPR AFVITRSGPT SRSSSYSARQ SYGSRSSITP GVYQQLSSSG
ITDFRGTREK EKREMQNLNE RLAGYIEKVH FLDAQVKKLE AENEALRNRK SESLQPIRDA
YENELAQARK VIDELSSTKG VSEAKVAGLQ DEIASLRELI GTYENQSKDY RKKIESLGNQ
IGEYEGELHT LRIRCGSLED ENAKVRELLD KIQDQNRRLR ADLDTETSAH IEADCLAQTK
TEECEFYKDL LDQLELLKPE PMQIKGMDYA EFWKSELSKC VRDIQSAYDE KIDIIQQDIE
AKYSSQINSL RSGNVKDGMQ LQHVQEEVKK LRTQAGEKNA AYAELAAKFA SLQAERDAIG
RQCSELEREL EELRIKYNQD IGDLSNELSA VLAQLQTLTD VKITMELEIA CYRKLLEGEE
SRVGLRSLVE QAIGVQGRGT ASLKDTIQQS