ID   IFF11_CANAL             Reviewed;         511 AA.
AC   Q5A7R7; A0A1D8PJ00;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Cell wall protein IFF11;
DE   AltName: Full=Adhesin-like protein IFF11;
DE   Flags: Precursor;
GN   Name=IFF11; OrderedLocusNames=CAALFM_C300600WA;
GN   ORFNames=CaO19.12854, CaO19.5399;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=17371861; DOI=10.1128/iai.00102-07;
RA   Bates S., de la Rosa J.M., MacCallum D.M., Brown A.J., Gow N.A., Odds F.C.;
RT   "Candida albicans Iff11, a secreted protein required for cell wall
RT   structure and virulence.";
RL   Infect. Immun. 75:2922-2928(2007).
RN   [5]
RP   INDUCTION.
RX   PubMed=21592964; DOI=10.1074/jbc.m111.233569;
RA   Singh R.P., Prasad H.K., Sinha I., Agarwal N., Natarajan K.;
RT   "Cap2-HAP complex is a critical transcriptional regulator that has dual but
RT   contrasting roles in regulation of iron homeostasis in Candida albicans.";
RL   J. Biol. Chem. 286:25154-25170(2011).
CC   -!- FUNCTION: GPI-anchored cell wall protein involved in cell wall
CC       organization, hyphal growth, as well as in host-fungal interaction and
CC       virulence. {ECO:0000269|PubMed:17371861}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000269|PubMed:17371861}.
CC   -!- INDUCTION: Repressed by HAP43. {ECO:0000269|PubMed:21592964}.
CC   -!- PTM: O-glycosylated. {ECO:0000269|PubMed:17371861}.
CC   -!- DISRUPTION PHENOTYPE: Leads to hypersensitivity to cell wall-damaging
CC       agents and highly attenuated in a murine model of systemic infection.
CC       {ECO:0000269|PubMed:17371861}.
CC   -!- MISCELLANEOUS: IFF11 differs from other HYR1/IFF family members in
CC       lacking a GPI-anchor.
CC   -!- SIMILARITY: Belongs to the HYR1/IFF family. {ECO:0000305}.
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DR   EMBL; CP017625; AOW28110.1; -; Genomic_DNA.
DR   RefSeq; XP_717774.1; XM_712681.1.
DR   AlphaFoldDB; Q5A7R7; -.
DR   SMR; Q5A7R7; -.
DR   GeneID; 3640580; -.
DR   KEGG; cal:CAALFM_C300600WA; -.
DR   CGD; CAL0000200354; IFF11.
DR   VEuPathDB; FungiDB:C3_00600W_A; -.
DR   HOGENOM; CLU_006199_3_1_1; -.
DR   InParanoid; Q5A7R7; -.
DR   OMA; ANGSHKI; -.
DR   OrthoDB; 1483197at2759; -.
DR   PRO; PR:Q5A7R7; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0009986; C:cell surface; IDA:CGD.
DR   GO; GO:0005576; C:extracellular region; IDA:CGD.
DR   GO; GO:0009277; C:fungal-type cell wall; IDA:CGD.
DR   InterPro; IPR025928; Flocculin_t3_rpt.
DR   InterPro; IPR021031; Hyphal-reg_cell_wall_N.
DR   Pfam; PF13928; Flocculin_t3; 1.
DR   Pfam; PF11765; Hyphal_reg_CWP; 1.
PE   1: Evidence at protein level;
KW   Cell wall; Glycoprotein; Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..511
FT                   /note="Cell wall protein IFF11"
FT                   /id="PRO_0000424770"
FT   REGION          349..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        245
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   511 AA;  53359 MW;  06030C38B217156A CRC64;
     MLLSNLVIPL LATSATVSAT FDVTSSLTKY AAFDFGVGDI SIQKSASFSL INTFDCAFQG
     DINIEKDCEF LIASTAKALK LTFNNIFHKI ENKGKWIVHT LESAAASTCN IIVKSFVNTG
     EIILAFKGHV LAPIINIAAS HWVNHGCLHL FQEIKSISVA ILGVVGGTIE NHGTICLTNQ
     LCKQVTKIIG SGCIALEKSS SFFISNSFLS IDAQHTFYLG EGNPTIQAQA VSLPQTFKVA
     NFGANGSHKI GLNLPLLSIT IAGKKGWSYD TKTGILTLTA NGFISQKFDI GLGYDPSKFE
     VCTDNSVGIV SVIKGSIKYN GPCPHAGRPS VCQICPGVPT PPVITSSATA ITSTQSKTTS
     SSSTSSIATT STTSSKPKPT TVSTSSIAST TTPDGSYSTS FVTVTAETTK VVTITSCSNN
     ACHPTTAPTG LTVVTLTTSD VKTVVTTYCP LTQTVTLGVT GTKTVDLGCP TGYFGYNGYI
     GKGVSIGHGG AAASASAGFQ IGFDIFKNHH F