ID   IFFO2_HUMAN             Reviewed;         517 AA.
AC   Q5TF58; Q9H7K0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 3.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Intermediate filament family orphan 2;
GN   Name=IFFO2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 327-517.
RC   TISSUE=Spleen;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; AL080251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK024480; BAB15770.1; -; mRNA.
DR   CCDS; CCDS44076.1; -.
DR   RefSeq; NP_001129737.1; NM_001136265.1.
DR   AlphaFoldDB; Q5TF58; -.
DR   SMR; Q5TF58; -.
DR   BioGRID; 126024; 18.
DR   IntAct; Q5TF58; 4.
DR   STRING; 9606.ENSP00000387941; -.
DR   iPTMnet; Q5TF58; -.
DR   PhosphoSitePlus; Q5TF58; -.
DR   BioMuta; IFFO2; -.
DR   DMDM; 327478574; -.
DR   EPD; Q5TF58; -.
DR   MassIVE; Q5TF58; -.
DR   MaxQB; Q5TF58; -.
DR   PaxDb; Q5TF58; -.
DR   PeptideAtlas; Q5TF58; -.
DR   PRIDE; Q5TF58; -.
DR   ProteomicsDB; 65074; -.
DR   Antibodypedia; 2914; 32 antibodies from 12 providers.
DR   DNASU; 126917; -.
DR   Ensembl; ENST00000455833.7; ENSP00000387941.2; ENSG00000169991.11.
DR   GeneID; 126917; -.
DR   KEGG; hsa:126917; -.
DR   MANE-Select; ENST00000455833.7; ENSP00000387941.2; NM_001136265.2; NP_001129737.1.
DR   UCSC; uc001bbd.3; human.
DR   CTD; 126917; -.
DR   DisGeNET; 126917; -.
DR   GeneCards; IFFO2; -.
DR   HGNC; HGNC:27006; IFFO2.
DR   HPA; ENSG00000169991; Group enriched (esophagus, skin).
DR   neXtProt; NX_Q5TF58; -.
DR   OpenTargets; ENSG00000169991; -.
DR   VEuPathDB; HostDB:ENSG00000169991; -.
DR   eggNOG; ENOG502QW7N; Eukaryota.
DR   GeneTree; ENSGT00510000046803; -.
DR   HOGENOM; CLU_039629_2_1_1; -.
DR   InParanoid; Q5TF58; -.
DR   OMA; AACCRRK; -.
DR   OrthoDB; 792412at2759; -.
DR   PhylomeDB; Q5TF58; -.
DR   TreeFam; TF331217; -.
DR   PathwayCommons; Q5TF58; -.
DR   SignaLink; Q5TF58; -.
DR   BioGRID-ORCS; 126917; 8 hits in 1071 CRISPR screens.
DR   ChiTaRS; IFFO2; human.
DR   GenomeRNAi; 126917; -.
DR   Pharos; Q5TF58; Tdark.
DR   PRO; PR:Q5TF58; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5TF58; protein.
DR   Bgee; ENSG00000169991; Expressed in upper arm skin and 149 other tissues.
DR   ExpressionAtlas; Q5TF58; baseline and differential.
DR   Genevisible; Q5TF58; HS.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR039008; IF_rod_dom.
DR   Pfam; PF00038; Filament; 1.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Reference proteome.
FT   CHAIN           1..517
FT                   /note="Intermediate filament family orphan 2"
FT                   /id="PRO_0000326185"
FT   DOMAIN          53..484
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          104..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          478..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..499
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   517 AA;  57328 MW;  F5A9FCEA675DF445 CRC64;
     MVNSLLFGEM ALAFGCPPGG GGGGCPGGGG GGGGAGPGPS PVTAALRDDL GSNIHLLKGL
     NVRFRCFLAK VHELERRNRL LEKQLEQQQS ERERRLRYKT FSREQAVQTG PELLRPPAPG
     GGHGLSSGAA AGANANAVAL GGLPPGGGSH PQHYGRLPGT IWSYTQVRRT GGGGVETVQG
     PGVSWVHPDG VGVQIDTITP EIRALYNVLA KVKRERDEYK RRWEEELAKR MNLQTMVDTL
     QEAAQEADAI QEEMNEKIER LKAELVVFKG LMSDPMTDLD TKIQEKAMKV DMDICRRIDI
     TAKLCDVAQQ RNSEDVSKIF QVVPKKKERK VASDDDISEQ DGEVNRFSDD EVGSMNITDE
     MKRMFNQLRE TFDFDDDCDS LTWEENEDTL LLWEDFTNCN PTIDLQGEQE ENLGNLIHET
     ESFFKTRDKE YQETIGQIEL ELATAKSDMN RHLHEYMEMC SMKRGLDVQM ETCRRLIKGS
     ADRNSPSPSS VASSDSGSTD EIQDEFEREA DVEPMVS