IFFO2_MOUSE
ID IFFO2_MOUSE Reviewed; 512 AA.
AC Q8R2V2;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Intermediate filament family orphan 2;
GN Name=Iffo2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-143.
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27170.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH27170.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; BC027170; AAH27170.1; ALT_SEQ; mRNA.
DR EMBL; BG175340; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BB620602; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS57308.1; -.
DR RefSeq; NP_001192102.1; NM_001205173.1.
DR RefSeq; NP_898971.1; NM_183148.3.
DR AlphaFoldDB; Q8R2V2; -.
DR SMR; Q8R2V2; -.
DR BioGRID; 229345; 2.
DR IntAct; Q8R2V2; 7.
DR STRING; 10090.ENSMUSP00000134062; -.
DR iPTMnet; Q8R2V2; -.
DR PhosphoSitePlus; Q8R2V2; -.
DR MaxQB; Q8R2V2; -.
DR PaxDb; Q8R2V2; -.
DR PRIDE; Q8R2V2; -.
DR ProteomicsDB; 267104; -.
DR Ensembl; ENSMUST00000174078; ENSMUSP00000134062; ENSMUSG00000041025.
DR GeneID; 212632; -.
DR KEGG; mmu:212632; -.
DR UCSC; uc008vmn.2; mouse.
DR CTD; 126917; -.
DR MGI; MGI:2140675; Iffo2.
DR VEuPathDB; HostDB:ENSMUSG00000041025; -.
DR eggNOG; ENOG502QW7N; Eukaryota.
DR GeneTree; ENSGT00510000046803; -.
DR HOGENOM; CLU_039629_2_1_1; -.
DR InParanoid; Q8R2V2; -.
DR OMA; RSQYVNM; -.
DR OrthoDB; 792412at2759; -.
DR PhylomeDB; Q8R2V2; -.
DR TreeFam; TF331217; -.
DR BioGRID-ORCS; 212632; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Iffo2; mouse.
DR PRO; PR:Q8R2V2; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8R2V2; protein.
DR Bgee; ENSMUSG00000041025; Expressed in tail skin and 164 other tissues.
DR ExpressionAtlas; Q8R2V2; baseline and differential.
DR Genevisible; Q8R2V2; MM.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR039008; IF_rod_dom.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Reference proteome.
FT CHAIN 1..512
FT /note="Intermediate filament family orphan 2"
FT /id="PRO_0000326186"
FT DOMAIN 50..479
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 473..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 56994 MW; D6294D1E08A4B34C CRC64;
MVNSLLFGEM ALAFGCPPGG GGCAGGGGGG GAGPGPSPVT AALRDDLGSN IHLLKGLNVR
FRCFLAKVHE LERRNRLLEK QLEQQQSERD RRLRYKTFSR EQAVQTGPEL LRPSAAGSGQ
ALGAATGVNA NAVALGGLPP GGGSHPQHYG RLPGTIWSYT QVRRTGGGGV ETVQGPGVSW
VHPDGVGVQI DTITPEIRAL YNVLAKVKRE RDEYKRRWEE ELAKRMNLQT MVDTLQEAAQ
EAEAIQEEMN EKIERLKAEL VVFKGLMSDP MTDLDTKIQE KAMKVDMDIC RRIDITAKLC
DVAQQRNSED VSKIFQVVPK KKDRKVASDE DISEQDGEVN RFSDEEVGSM NITDEMKRMF
NQLRETFDFD DDCDSLTWEE NEDTLLLWED FTNCNPTIDL QGEQEENLGN LIHETESFFK
TRDKEYQETI GQIELELATA KSDMNRHLHE YMEMCSMKRG LDVQMETCRR LIKGSADRNS
PSPSSVASSD SGSTDEIQED LEREADVEPM VS
