IFG15_HUMAN
ID IFG15_HUMAN Reviewed; 131 AA.
AC Q9H496; Q05BU2;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Torsin-1A-interacting protein 2, isoform IFRG15;
DE AltName: Full=15 kDa interferon-responsive protein;
DE Short=IFRG15;
GN Name=TOR1AIP2; Synonyms=IFRG15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION BY INTERFERON.
RC TISSUE=Lymphoma;
RA Dron M., Meritet J.F., Tovey M.G.;
RT "Characterization of novel interferon responsive genes.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9H496; P22607: FGFR3; NbExp=3; IntAct=EBI-2510146, EBI-348399;
CC Q9H496; P06396: GSN; NbExp=3; IntAct=EBI-2510146, EBI-351506;
CC Q9H496; Q93062: RBPMS; NbExp=3; IntAct=EBI-2510146, EBI-740322;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=IFRG15;
CC IsoId=Q9H496-1; Sequence=Displayed;
CC Name=TOR1AIP2;
CC IsoId=Q8NFQ8-1; Sequence=External;
CC -!- INDUCTION: Induced by interferon alpha. {ECO:0000269|Ref.1}.
CC -!- MISCELLANEOUS: [Isoform IFRG15]: Dubious isoform.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32790.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AJ299406; CAC13974.1; -; mRNA.
DR EMBL; AK289793; BAF82482.1; -; mRNA.
DR EMBL; AL359853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW91065.1; -; Genomic_DNA.
DR EMBL; BC032790; AAH32790.1; ALT_SEQ; mRNA.
DR EMBL; BC096704; AAH96704.1; -; mRNA.
DR EMBL; BC098170; AAH98170.1; -; mRNA.
DR EMBL; BC098309; AAH98309.1; -; mRNA.
DR EMBL; BC098348; AAH98348.1; -; mRNA.
DR CCDS; CCDS53439.1; -. [Q9H496-1]
DR RefSeq; NP_071742.1; NM_022347.3. [Q9H496-1]
DR RefSeq; XP_016855966.1; XM_017000477.1.
DR RefSeq; XP_016855967.1; XM_017000478.1.
DR AlphaFoldDB; Q9H496; -.
DR BioGRID; 127870; 238.
DR IntAct; Q9H496; 12.
DR iPTMnet; Q9H496; -.
DR PhosphoSitePlus; Q9H496; -.
DR BioMuta; TOR1AIP2; -.
DR EPD; Q9H496; -.
DR jPOST; Q9H496; -.
DR MassIVE; Q9H496; -.
DR MaxQB; Q9H496; -.
DR PaxDb; Q9H496; -.
DR PeptideAtlas; Q9H496; -.
DR PRIDE; Q9H496; -.
DR ProteomicsDB; 80800; -. [Q9H496-1]
DR Antibodypedia; 60527; 75 antibodies from 16 providers.
DR DNASU; 163590; -.
DR Ensembl; ENST00000482587.5; ENSP00000485355.1; ENSG00000169905.13. [Q9H496-1]
DR GeneID; 163590; -.
DR UCSC; uc001gnn.4; human. [Q9H496-1]
DR CTD; 163590; -.
DR DisGeNET; 163590; -.
DR GeneCards; TOR1AIP2; -.
DR HGNC; HGNC:24055; TOR1AIP2.
DR HPA; ENSG00000169905; Low tissue specificity.
DR MalaCards; TOR1AIP2; -.
DR MIM; 614513; gene.
DR neXtProt; NX_Q9H496; -.
DR OpenTargets; ENSG00000169905; -.
DR VEuPathDB; HostDB:ENSG00000169905; -.
DR GeneTree; ENSGT00390000012166; -.
DR HOGENOM; CLU_2139075_0_0_1; -.
DR InParanoid; Q9H496; -.
DR OrthoDB; 575658at2759; -.
DR PhylomeDB; Q9H496; -.
DR PathwayCommons; Q9H496; -.
DR SignaLink; Q9H496; -.
DR BioGRID-ORCS; 163590; 74 hits in 1090 CRISPR screens.
DR ChiTaRS; TOR1AIP2; human.
DR GenomeRNAi; 163590; -.
DR Pharos; Q9H496; Tbio.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000169905; Expressed in adrenal tissue and 205 other tissues.
DR ExpressionAtlas; Q9H496; baseline and differential.
DR Genevisible; Q9H496; HS.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..131
FT /note="Torsin-1A-interacting protein 2, isoform IFRG15"
FT /id="PRO_0000421071"
SQ SEQUENCE 131 AA; 15348 MW; 858F0B2886A3D61A CRC64;
MFSDNSHCPD CGQQWFPSLE LGHWLYQTEL VENECYQVFL DRINRADYCP ECYPDNPANR
SLVLPWSFPL EWAPQNLTRW TFEKACHPFL LGPPLVRKRI HDSRVAGFNP ALQLILTRTD
KTLNKKLGQN K
