IFG15_MOUSE
ID IFG15_MOUSE Reviewed; 131 AA.
AC Q9ER81; Q3U8P1; Q3UAA2; Q9D178;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Torsin-1A-interacting protein 2, isoform IFRG15;
DE AltName: Full=15 kDa interferon-responsive protein;
DE Short=IFRG15;
GN Name=Tor1aip2; Synonyms=Ifrg15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION BY INTERFERON.
RC STRAIN=DBA/2J;
RA Meritet J.F., Dron M., Tovey M.;
RT "characterization of ifrg15 and ifrg28, two newly identified interferon
RT responsive gene.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=22871540; DOI=10.1016/j.gene.2012.07.030;
RA Wu F.R., Ding B., Qi B., Shang M.B., Yang X.X., Liu Y., Li W.Y.;
RT "Sequence analysis, expression patterns and transcriptional regulation of
RT mouse Ifrg15 during preimplantation embryonic development.";
RL Gene 507:119-124(2012).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Ifrg15;
CC IsoId=Q9ER81-1; Sequence=Displayed;
CC Name=Tor1aip2;
CC IsoId=Q8BYU6-1; Sequence=External;
CC -!- DEVELOPMENTAL STAGE: Expressed in oocytes and preimplantation embryos
CC with expression peaking at the blastocyst stage.
CC -!- INDUCTION: Induced by interferon alpha. {ECO:0000269|Ref.1}.
CC -!- MISCELLANEOUS: [Isoform Ifrg15]: Dubious isoform.
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DR EMBL; AJ251363; CAC13975.1; -; mRNA.
DR EMBL; AK003852; BAB23037.1; -; mRNA.
DR EMBL; AK032697; BAC27991.1; -; mRNA.
DR EMBL; AK150117; BAE29320.1; -; mRNA.
DR EMBL; AK150303; BAE29454.1; -; mRNA.
DR EMBL; AK151453; BAE30413.1; -; mRNA.
DR EMBL; AK152137; BAE30976.1; -; mRNA.
DR EMBL; AC159964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC064017; AAH64017.1; -; mRNA.
DR EMBL; BC092059; AAH92059.1; -; mRNA.
DR CCDS; CCDS15388.1; -. [Q9ER81-1]
DR RefSeq; NP_001153652.1; NM_001160180.1. [Q9ER81-1]
DR RefSeq; NP_001153653.1; NM_001160181.1. [Q9ER81-1]
DR RefSeq; NP_001153654.1; NM_001160182.1. [Q9ER81-1]
DR RefSeq; NP_071724.1; NM_022329.4. [Q9ER81-1]
DR AlphaFoldDB; Q9ER81; -.
DR BioGRID; 232245; 3.
DR PhosphoSitePlus; Q9ER81; -.
DR EPD; Q9ER81; -.
DR MaxQB; Q9ER81; -.
DR PaxDb; Q9ER81; -.
DR PRIDE; Q9ER81; -.
DR ProteomicsDB; 267105; -. [Q9ER81-1]
DR Antibodypedia; 60527; 75 antibodies from 16 providers.
DR DNASU; 240832; -.
DR Ensembl; ENSMUST00000065648; ENSMUSP00000067353; ENSMUSG00000050565. [Q9ER81-1]
DR Ensembl; ENSMUST00000097526; ENSMUSP00000095133; ENSMUSG00000050565. [Q9ER81-1]
DR Ensembl; ENSMUST00000111754; ENSMUSP00000107383; ENSMUSG00000050565. [Q9ER81-1]
DR Ensembl; ENSMUST00000128941; ENSMUSP00000135107; ENSMUSG00000050565. [Q9ER81-1]
DR GeneID; 240832; -.
DR KEGG; mmu:240832; -.
DR UCSC; uc007dby.2; mouse. [Q9ER81-1]
DR CTD; 163590; -.
DR MGI; MGI:3582695; Tor1aip2.
DR VEuPathDB; HostDB:ENSMUSG00000050565; -.
DR GeneTree; ENSGT00390000012166; -.
DR HOGENOM; CLU_2139075_0_0_1; -.
DR PhylomeDB; Q9ER81; -.
DR BioGRID-ORCS; 240832; 7 hits in 69 CRISPR screens.
DR ChiTaRS; Tor1aip2; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000050565; Expressed in placenta labyrinth and 278 other tissues.
DR ExpressionAtlas; Q9ER81; baseline and differential.
DR Genevisible; Q9ER81; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0001671; F:ATPase activator activity; ISO:MGI.
DR GO; GO:0051117; F:ATPase binding; ISO:MGI.
DR GO; GO:0007029; P:endoplasmic reticulum organization; ISO:MGI.
DR GO; GO:0061024; P:membrane organization; IBA:GO_Central.
DR GO; GO:0032781; P:positive regulation of ATP-dependent activity; ISO:MGI.
DR GO; GO:0090435; P:protein localization to nuclear envelope; ISO:MGI.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..131
FT /note="Torsin-1A-interacting protein 2, isoform IFRG15"
FT /id="PRO_0000421072"
FT CONFLICT 95
FT /note="L -> M (in Ref. 2; BAE30976)"
FT /evidence="ECO:0000305"
FT CONFLICT 97
FT /note="R -> K (in Ref. 2; BAE30413)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="K -> R (in Ref. 2; BAB23037/BAE30413)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 131 AA; 15278 MW; 93DC9F1886A3D0C1 CRC64;
MFSDNSHCPD CGQQWFPSLE LGHWLYQTEL VENECYQVFL DRINRADYCP ECYPDNPANR
SLVLPWSFPL EWAPQNLTRW TFEKACHPFL LGPPLVRKKI HDSRVAGFNP ALQLILSRTD
KTLNKKLGQS K
