IFI44_HUMAN
ID IFI44_HUMAN Reviewed; 444 AA.
AC Q8TCB0; B7ZAG3; D3DQ80; Q14496;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Interferon-induced protein 44;
DE Short=p44;
DE AltName: Full=Microtubule-associated protein 44;
GN Name=IFI44; Synonyms=MTAP44;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND INDUCTION.
RX PubMed=7925411; DOI=10.1111/j.1432-1033.1994.00877.x;
RA Kitamura A., Takahashi K., Okajima A., Kitamura N.;
RT "Induction of the human gene for p44, a hepatitis-C-associated microtubular
RT aggregate protein, by interferon-alpha/beta.";
RL Eur. J. Biochem. 224:877-883(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-9.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: This protein aggregates to form microtubular structures.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q8TCB0; P43364: MAGEA11; NbExp=3; IntAct=EBI-2831730, EBI-739552;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TCB0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TCB0-2; Sequence=VSP_057031, VSP_057032;
CC -!- INDUCTION: By alpha and beta interferons, but not by gamma interferons.
CC {ECO:0000269|PubMed:7925411}.
CC -!- SIMILARITY: Belongs to the IFI44 family. {ECO:0000305}.
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DR EMBL; D28915; BAA06043.1; -; Genomic_DNA.
DR EMBL; AK316278; BAH14649.1; -; mRNA.
DR EMBL; AC104837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX06347.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX06348.1; -; Genomic_DNA.
DR EMBL; BC022870; AAH22870.1; -; mRNA.
DR CCDS; CCDS688.1; -. [Q8TCB0-1]
DR RefSeq; NP_006408.3; NM_006417.4. [Q8TCB0-1]
DR AlphaFoldDB; Q8TCB0; -.
DR BioGRID; 115812; 4.
DR IntAct; Q8TCB0; 5.
DR STRING; 9606.ENSP00000359783; -.
DR iPTMnet; Q8TCB0; -.
DR PhosphoSitePlus; Q8TCB0; -.
DR BioMuta; IFI44; -.
DR DMDM; 224471836; -.
DR jPOST; Q8TCB0; -.
DR MassIVE; Q8TCB0; -.
DR MaxQB; Q8TCB0; -.
DR PaxDb; Q8TCB0; -.
DR PeptideAtlas; Q8TCB0; -.
DR PRIDE; Q8TCB0; -.
DR ProteomicsDB; 7066; -.
DR ProteomicsDB; 74109; -. [Q8TCB0-1]
DR Antibodypedia; 19746; 150 antibodies from 24 providers.
DR DNASU; 10561; -.
DR Ensembl; ENST00000370747.9; ENSP00000359783.4; ENSG00000137965.11. [Q8TCB0-1]
DR GeneID; 10561; -.
DR KEGG; hsa:10561; -.
DR MANE-Select; ENST00000370747.9; ENSP00000359783.4; NM_006417.5; NP_006408.3.
DR UCSC; uc001dip.5; human. [Q8TCB0-1]
DR CTD; 10561; -.
DR DisGeNET; 10561; -.
DR GeneCards; IFI44; -.
DR HGNC; HGNC:16938; IFI44.
DR HPA; ENSG00000137965; Tissue enhanced (bone).
DR MIM; 610468; gene.
DR neXtProt; NX_Q8TCB0; -.
DR OpenTargets; ENSG00000137965; -.
DR PharmGKB; PA29647; -.
DR VEuPathDB; HostDB:ENSG00000137965; -.
DR eggNOG; ENOG502QQ57; Eukaryota.
DR GeneTree; ENSGT00940000162964; -.
DR HOGENOM; CLU_049888_3_1_1; -.
DR InParanoid; Q8TCB0; -.
DR OMA; NSMKPIT; -.
DR OrthoDB; 570957at2759; -.
DR PhylomeDB; Q8TCB0; -.
DR TreeFam; TF328728; -.
DR PathwayCommons; Q8TCB0; -.
DR SignaLink; Q8TCB0; -.
DR BioGRID-ORCS; 10561; 7 hits in 1069 CRISPR screens.
DR GenomeRNAi; 10561; -.
DR Pharos; Q8TCB0; Tbio.
DR PRO; PR:Q8TCB0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TCB0; protein.
DR Bgee; ENSG00000137965; Expressed in monocyte and 176 other tissues.
DR ExpressionAtlas; Q8TCB0; baseline and differential.
DR Genevisible; Q8TCB0; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR GO; GO:0009615; P:response to virus; TAS:ProtInc.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR024644; IFI44_fam.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006571; TLDc_dom.
DR PANTHER; PTHR14241:SF3; PTHR14241:SF3; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51886; TLDC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Reference proteome.
FT CHAIN 1..444
FT /note="Interferon-induced protein 44"
FT /id="PRO_0000084165"
FT DOMAIN 1..152
FT /note="TLDc"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT VAR_SEQ 1..283
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057031"
FT VAR_SEQ 372..443
FT /note="LEEVQRKLGFALSDISVVSNYSSEWELDPVKDVLILSALRRMLWAADDFLED
FT LPFEQIGNLREEIINCAQGK -> VMNDALRKHIFWGMLLQSHTSVYKNKNKQLLGLRR
FT ITKLL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057032"
FT VARIANT 9
FT /note="W -> R (in dbSNP:rs2070123)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_054647"
FT CONFLICT 198
FT /note="G -> P (in Ref. 1; BAA06043)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="R -> Q (in Ref. 1; BAA06043)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 444 AA; 50491 MW; C9B699ECD4523D0F CRC64;
MAVTTRLTWL HEKILQNHFG GKRLSLLYKG SVHGFRNGVL LDRCCNQGPT LTVIYSEDHI
IGAYAEESYQ EGKYASIILF ALQDTKISEW KLGLCTPETL FCCDVTKYNS PTNFQIDGRN
RKVIMDLKTM ENLGLAQNCT ISIQDYEVFR CEDSLDERKI KGVIELRKSL LSALRTYEPY
GSLVQQIRIL LLGPIGAGKS SFFNSVRSVF QGHVTHQALV GTNTTGISEK YRTYSIRDGK
DGKYLPFILC DSLGLSEKEG GLCRDDIFYI LNGNIRDRYQ FNPMESIKLN HHDYIDSPSL
KDRIHCVAFV FDASSIQYFS SQMIVKIKRI RRELVNAGVV HVALLTHVDS MDLITKGDLI
EIERCEPVRS KLEEVQRKLG FALSDISVVS NYSSEWELDP VKDVLILSAL RRMLWAADDF
LEDLPFEQIG NLREEIINCA QGKK
