ID   IFI44_MOUSE             Reviewed;         422 AA.
AC   Q8BV66; Q9ER37;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Interferon-induced protein 44;
DE   AltName: Full=Microtubule-associated protein 44;
GN   Name=Ifi44; Synonyms=Mtap44;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RA   Dron M., Meritet J.F., Tovey M.G.;
RT   "Characterization of novel interferon responsive genes.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Cecum, Spleen, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: This protein aggregates to form microtubular structures.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the IFI44 family. {ECO:0000305}.
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DR   EMBL; AJ299405; CAC13979.1; -; mRNA.
DR   EMBL; AK079749; BAC37740.1; -; mRNA.
DR   EMBL; AK136553; BAE23041.1; -; mRNA.
DR   EMBL; AK171676; BAE42605.1; -; mRNA.
DR   EMBL; BC111882; AAI11883.1; -; mRNA.
DR   CCDS; CCDS17911.1; -.
DR   RefSeq; NP_598632.2; NM_133871.2.
DR   AlphaFoldDB; Q8BV66; -.
DR   BioGRID; 221342; 2.
DR   STRING; 10090.ENSMUSP00000029671; -.
DR   iPTMnet; Q8BV66; -.
DR   PhosphoSitePlus; Q8BV66; -.
DR   SwissPalm; Q8BV66; -.
DR   MaxQB; Q8BV66; -.
DR   PaxDb; Q8BV66; -.
DR   PeptideAtlas; Q8BV66; -.
DR   PRIDE; Q8BV66; -.
DR   ProteomicsDB; 266949; -.
DR   Antibodypedia; 19746; 150 antibodies from 24 providers.
DR   DNASU; 99899; -.
DR   Ensembl; ENSMUST00000029671; ENSMUSP00000029671; ENSMUSG00000028037.
DR   GeneID; 99899; -.
DR   KEGG; mmu:99899; -.
DR   UCSC; uc008rsk.2; mouse.
DR   CTD; 10561; -.
DR   MGI; MGI:2443016; Ifi44.
DR   VEuPathDB; HostDB:ENSMUSG00000028037; -.
DR   eggNOG; ENOG502QQ57; Eukaryota.
DR   GeneTree; ENSGT00940000162964; -.
DR   HOGENOM; CLU_049888_3_1_1; -.
DR   InParanoid; Q8BV66; -.
DR   OMA; NSMKPIT; -.
DR   OrthoDB; 570957at2759; -.
DR   PhylomeDB; Q8BV66; -.
DR   TreeFam; TF328728; -.
DR   BioGRID-ORCS; 99899; 0 hits in 71 CRISPR screens.
DR   ChiTaRS; Ifi44; mouse.
DR   PRO; PR:Q8BV66; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q8BV66; protein.
DR   Bgee; ENSMUSG00000028037; Expressed in small intestine Peyer's patch and 103 other tissues.
DR   Genevisible; Q8BV66; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR024644; IFI44_fam.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006571; TLDc_dom.
DR   PANTHER; PTHR14241:SF3; PTHR14241:SF3; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..422
FT                   /note="Interferon-induced protein 44"
FT                   /id="PRO_0000337871"
FT   DOMAIN          1..147
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT   CONFLICT        233
FT                   /note="A -> V (in Ref. 1; CAC13979 and 3; AAI11883)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   422 AA;  47852 MW;  FBE1070ABF1D4F5E CRC64;
     MAMRTRLTWQ QEKCLQNYFG GKRFCLLYKA SVQKFSHQNL LCTCENQGPT MIVVYSEKCV
     IGMYLKEGFQ GKDVSITIFA LQETGFSLCA KGPDSPYLLF HKRKTNDFSI LLDEKAVIVS
     SAICKMLQLT ARNNVIPIQE CEAFRCEELL DERKTRGIAV LHSNLLQALR DYKPYGDLVQ
     QTRVLLLGPI GAGKSSFVNS VKSVFKGSIT HQILVGCDED GISDKYRTYS IKAKDDSDPL
     PFILCDSLGL GENAGLHTDD VWHILKGHTP DRYQFDSMKP ITSNHPNYTH DPLLKDRIHC
     VVFVFDINSF EMHSSELVAK IKKIRRDLIK HGILHLALLT HVDSLDLITK EDMTDIYNYS
     PVKSKLEAFH GVFGFALSDI LVVSNYVSEW QLDPVKDMLI LSALKEILYT ANEFLEDLPL
     NK