ID   IFI44_PANTR             Reviewed;         444 AA.
AC   P27473;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Interferon-induced protein 44;
DE   AltName: Full=Antigen p44;
DE   AltName: Full=Non-A non-B hepatitis-associated microtubular aggregates protein;
GN   Name=IFI44;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 14-22; 108-128 AND
RP   231-240.
RC   TISSUE=Liver;
RX   PubMed=2170570; DOI=10.1099/0022-1317-71-9-2005;
RA   Takahashi K., Kitamura N., Shibui T., Kamizono M., Matsui R., Yoshiyama Y.,
RA   Maeda T., Kondo J., Honda Y., Yamada E., Shimizu Y.K., Teranishi Y.,
RA   Nakanishi S.;
RT   "Cloning, sequencing and expression in Escherichia coli of cDNA for a non-
RT   A, non-B hepatitis-associated microtubular aggregates protein.";
RL   J. Gen. Virol. 71:2005-2011(1990).
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   PubMed=2170569; DOI=10.1099/0022-1317-71-9-1999;
RA   Honda Y., Kondo J., Maeda T., Yoshiyama Y., Yamada E., Shimizu Y.K.,
RA   Shikata T., Ono Y.;
RT   "Isolation and purification of a non-A, non-B hepatitis-associated
RT   microtubular aggregates protein.";
RL   J. Gen. Virol. 71:1999-2004(1990).
CC   -!- FUNCTION: This protein aggregates to form microtubular structures.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Hepatocytes.
CC   -!- INDUCTION: During infection of non-A non-B hepatitis virus or hepatitis
CC       delta virus.
CC   -!- SIMILARITY: Belongs to the IFI44 family. {ECO:0000305}.
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DR   EMBL; D90034; BAA14082.1; -; mRNA.
DR   PIR; A43676; A43676.
DR   RefSeq; NP_001038962.1; NM_001045497.2.
DR   AlphaFoldDB; P27473; -.
DR   STRING; 9598.ENSPTRP00000001546; -.
DR   PaxDb; P27473; -.
DR   Ensembl; ENSPTRT00000001694; ENSPTRP00000001546; ENSPTRG00000000893.
DR   GeneID; 456971; -.
DR   KEGG; ptr:456971; -.
DR   CTD; 10561; -.
DR   VGNC; VGNC:6881; IFI44.
DR   eggNOG; ENOG502QQ57; Eukaryota.
DR   GeneTree; ENSGT00940000162964; -.
DR   HOGENOM; CLU_049888_3_1_1; -.
DR   InParanoid; P27473; -.
DR   OMA; NSMKPIT; -.
DR   OrthoDB; 570957at2759; -.
DR   TreeFam; TF328728; -.
DR   Proteomes; UP000002277; Chromosome 1.
DR   Bgee; ENSPTRG00000000893; Expressed in spleen and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR024644; IFI44_fam.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006571; TLDc_dom.
DR   PANTHER; PTHR14241:SF3; PTHR14241:SF3; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Reference proteome.
FT   CHAIN           1..444
FT                   /note="Interferon-induced protein 44"
FT                   /id="PRO_0000084166"
FT   DOMAIN          1..152
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
SQ   SEQUENCE   444 AA;  50471 MW;  799CC855018CFA71 CRC64;
     MAVTTRLTWL HEKILQNHFG GKRLSLLYKG SVHGFHNGVL LDRCCNQGPT LTVIYSEDHI
     IGAYAEEGYQ ERKYASIILF ALQETKISEW KLGLYTPETL FCCDVAKYNS PTNFQIDGRN
     RKVIMDLKTM ENLGLAQNCT ISIQDYEVFR CEDSLDERKI KGVIELRKSL LSALRTYEPY
     GSLVQQIRIL LLGPIGAGKS SFFNSVRSVF QGHVTHQALV GTNTTGISEK YRTYSIRDGK
     DGKYLPFILC DSLGLSEKEG GLCMDDISYI LNGNIRDRYQ FNPMESIKLN HHDYIDSPSL
     KDRIHCVAFV FDASSIEYFS SQMIVKIKRI RRELVNAGVV HVALLTHVDS MDLITKGDLI
     EIERCVPVRS KLEEVQRKLG FALSDISVVS NYSSEWELDP VKDVLILSAL RRMLWAADDF
     LEDLPFEQIG NLREEIINCA QGKK