IFI5A_MOUSE
ID IFI5A_MOUSE Reviewed; 404 AA.
AC Q8CGE8; Q8BYE7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Interferon-activable protein 205-A;
DE Short=Ifi-205-A;
DE AltName: Full=Interferon-inducible protein p205-A;
DE AltName: Full=Protein D3';
GN Name=Ifi205a; Synonyms=Ifi205;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J.,
RA Wiemann S., Schick M., Korn B.;
RT "Cloning of mouse full open reading frames in Gateway(R) system entry
RT vector (pDONR201).";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=12809674; DOI=10.1016/s0888-7543(03)00092-2;
RA Deschamps S., Meyer J., Chatterjee G., Wang H., Lengyel P., Roe B.A.;
RT "The mouse Ifi200 gene cluster: genomic sequence, analysis, and comparison
RT with the human HIN-200 gene cluster.";
RL Genomics 82:34-46(2003).
CC -!- FUNCTION: May act as a transcriptional regulator in the myeloid
CC lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and
CC independent pathways (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HIN-200 family. {ECO:0000305}.
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DR EMBL; AK040191; BAC30535.1; -; mRNA.
DR EMBL; CT010211; CAJ18419.1; -; mRNA.
DR EMBL; BC040425; AAH40425.1; -; mRNA.
DR CCDS; CCDS15534.1; -.
DR RefSeq; NP_766236.2; NM_172648.3.
DR AlphaFoldDB; Q8CGE8; -.
DR SMR; Q8CGE8; -.
DR STRING; 10090.ENSMUSP00000062409; -.
DR iPTMnet; Q8CGE8; -.
DR PhosphoSitePlus; Q8CGE8; -.
DR SwissPalm; Q8CGE8; -.
DR EPD; Q8CGE8; -.
DR MaxQB; Q8CGE8; -.
DR PaxDb; Q8CGE8; -.
DR PeptideAtlas; Q8CGE8; -.
DR PRIDE; Q8CGE8; -.
DR ProteomicsDB; 266950; -.
DR DNASU; 226695; -.
DR Ensembl; ENSMUST00000059226; ENSMUSP00000062409; ENSMUSG00000054203.
DR GeneID; 226695; -.
DR KEGG; mmu:226695; -.
DR UCSC; uc007dsm.2; mouse.
DR CTD; 226695; -.
DR MGI; MGI:101847; Ifi205.
DR VEuPathDB; HostDB:ENSMUSG00000054203; -.
DR eggNOG; ENOG502QTQS; Eukaryota.
DR GeneTree; ENSGT00390000013296; -.
DR HOGENOM; CLU_020123_2_0_1; -.
DR InParanoid; Q8CGE8; -.
DR OMA; HNIKCEE; -.
DR OrthoDB; 1304994at2759; -.
DR PhylomeDB; Q8CGE8; -.
DR TreeFam; TF337385; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 226695; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Ifi205; mouse.
DR PRO; PR:Q8CGE8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8CGE8; protein.
DR Bgee; ENSMUSG00000054203; Expressed in zone of skin and 58 other tissues.
DR Genevisible; Q8CGE8; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:MGI.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
DR GO; GO:0002218; P:activation of innate immune response; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; ISO:MGI.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISO:MGI.
DR GO; GO:0035458; P:cellular response to interferon-beta; IDA:MGI.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; ISO:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IBA:GO_Central.
DR GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 2.40.50.140; -; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200; PTHR12200; 1.
DR Pfam; PF02760; HIN; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50834; HIN_200; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..404
FT /note="Interferon-activable protein 205-A"
FT /id="PRO_0000334527"
FT DOMAIN 1..88
FT /note="Pyrin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00061"
FT DOMAIN 192..392
FT /note="HIN-200"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00106"
FT REGION 85..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 250
FT /note="I -> V (in Ref. 1; BAC30535)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 45176 MW; 2221F59515F13951 CRC64;
MENEYKRLVL LEGLECINKH QFNLFKSLMV KDLNLEEDNQ EKYTTFQIAN MMVKKFPADA
GLDRLINFCE RVPTLKKRAE ILKKERSEVT EETSLEINRQ EASPATPTST TSHMLASERG
KTSTTQEETS TAQKRKGMSE EKTDVKKIKA SGKADQPPCC EGPTATCQSP ISQVSSSASS
NIPSAKNQKS QPQNQNIPRG AVLHSEPLTV MVLTATDPFE YESPEHEVKN MFHATVATVS
QYFHVKVFNI DLKEKFTKNN FITISNYFES KGILEINETS SVLEAAPKQM IEVPNCITRN
ANASPKICDI QKGTSGTVFY GVFTLHKKKV KTQNTSYEIK DGSGSIEVVG SGQWHNINCK
EGDKLHLFCF HLKRERGQPK LVCGDHSFVK VTKAGKKKEA STVQ
