ID   IFI6_BOVIN              Reviewed;         134 AA.
AC   Q6IED8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Interferon alpha-inducible protein 6 {ECO:0000305};
DE   AltName: Full=Interferon-induced protein 6-16 {ECO:0000303|PubMed:14728724};
DE            Short=Ifi-6-16 {ECO:0000303|PubMed:14728724};
GN   Name=IFI6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14728724; DOI=10.1186/1471-2164-5-8;
RA   Parker N., Porter A.C.G.;
RT   "Identification of a novel gene family that includes the interferon-
RT   inducible human genes 6-16 and ISG12.";
RL   BMC Genomics 5:8-8(2004).
CC   -!- FUNCTION: Plays a role in apoptosis, negatively regulating the
CC       intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis
CC       (By similarity). However, it has also been shown to have a pro-
CC       apoptotic activity (By similarity). May have an antiviral activity (By
CC       similarity). {ECO:0000250|UniProtKB:P09912}.
CC   -!- SUBUNIT: Interacts with CIB1; the interaction is direct.
CC       {ECO:0000250|UniProtKB:P09912}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P09912}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:P09912}.
CC   -!- SIMILARITY: Belongs to the IFI6/IFI27 family. {ECO:0000305}.
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DR   EMBL; BC111668; AAI11669.1; -; mRNA.
DR   EMBL; BN000173; CAD98145.1; -; mRNA.
DR   RefSeq; NP_001069056.1; NM_001075588.1.
DR   RefSeq; XP_005203178.1; XM_005203121.3.
DR   AlphaFoldDB; Q6IED8; -.
DR   STRING; 9913.ENSBTAP00000009939; -.
DR   PaxDb; Q6IED8; -.
DR   PRIDE; Q6IED8; -.
DR   Ensembl; ENSBTAT00000009939; ENSBTAP00000009939; ENSBTAG00000007554.
DR   Ensembl; ENSBTAT00000083399; ENSBTAP00000063610; ENSBTAG00000007554.
DR   GeneID; 512913; -.
DR   KEGG; bta:512913; -.
DR   CTD; 2537; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007554; -.
DR   VGNC; VGNC:30047; IFI6.
DR   eggNOG; ENOG502SCCP; Eukaryota.
DR   GeneTree; ENSGT00940000163178; -.
DR   HOGENOM; CLU_119109_0_0_1; -.
DR   InParanoid; Q6IED8; -.
DR   OMA; FWKALTY; -.
DR   OrthoDB; 1593440at2759; -.
DR   TreeFam; TF340510; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000007554; Expressed in corpus epididymis and 108 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:HGNC-UCL.
DR   GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR   GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0098586; P:cellular response to virus; ISS:UniProtKB.
DR   GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR   GO; GO:0097193; P:intrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:HGNC-UCL.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISS:HGNC.
DR   GO; GO:0051902; P:negative regulation of mitochondrial depolarization; ISS:HGNC-UCL.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; ISS:UniProtKB.
DR   GO; GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0001836; P:release of cytochrome c from mitochondria; ISS:HGNC-UCL.
DR   Gene3D; 6.10.110.10; -; 1.
DR   InterPro; IPR009311; IFI6/IFI27-like.
DR   InterPro; IPR038213; IFI6/IFI27-like_sf.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR16932; PTHR16932; 1.
DR   Pfam; PF06140; Ifi-6-16; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Apoptosis; Immunity; Innate immunity; Membrane;
KW   Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..134
FT                   /note="Interferon alpha-inducible protein 6"
FT                   /id="PRO_0000281926"
FT   TRANSMEM        7..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   134 AA;  13992 MW;  8B24FC6C23A67EF5 CRC64;
     MRQKAVSLFL CYLLLYTCGC CEEEDEKRYS EENSDSSFWG MVTYMAVGGG LMAAALPMLG
     FASTGIAANS LASSLMSWSA VANGGGVPAG GLVATLQSLG ASGGSALMAK IGAFLGYTVH
     KQVESRQKES KEKK