IFI6_PANTR
ID IFI6_PANTR Reviewed; 130 AA.
AC Q28808;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Interferon alpha-inducible protein 6 {ECO:0000305};
DE AltName: Full=Interferon-induced protein 6-16 {ECO:0000303|PubMed:14728724};
DE Short=Ifi-6-16 {ECO:0000303|PubMed:14728724};
GN Name=IFI6;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1381540; DOI=10.1016/0042-6822(92)90925-f;
RA Kato T., Esumi M., Yamashita S., Abe K., Shikata T.;
RT "Interferon-inducible gene expression in chimpanzee liver infected with
RT hepatitis C virus.";
RL Virology 190:856-860(1992).
RN [2]
RP IDENTIFICATION.
RX PubMed=14728724; DOI=10.1186/1471-2164-5-8;
RA Parker N., Porter A.C.G.;
RT "Identification of a novel gene family that includes the interferon-
RT inducible human genes 6-16 and ISG12.";
RL BMC Genomics 5:8-8(2004).
CC -!- FUNCTION: Plays a role in apoptosis, negatively regulating the
CC intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis
CC (By similarity). However, it has also been shown to have a pro-
CC apoptotic activity (By similarity). May have an antiviral activity (By
CC similarity). {ECO:0000250|UniProtKB:P09912}.
CC -!- SUBUNIT: Interacts with CIB1; the interaction is direct.
CC {ECO:0000250|UniProtKB:P09912}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P09912}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:P09912}.
CC -!- SIMILARITY: Belongs to the IFI6/IFI27 family. {ECO:0000305}.
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DR EMBL; D11384; BAA01980.1; -; mRNA.
DR EMBL; BN000256; CAE12274.1; -; mRNA.
DR RefSeq; NP_001009069.1; NM_001009069.1.
DR RefSeq; XP_016812747.1; XM_016957258.1.
DR AlphaFoldDB; Q28808; -.
DR STRING; 9598.ENSPTRP00000000720; -.
DR PaxDb; Q28808; -.
DR GeneID; 450178; -.
DR KEGG; ptr:450178; -.
DR CTD; 2537; -.
DR eggNOG; ENOG502SCCP; Eukaryota.
DR HOGENOM; CLU_119109_0_0_1; -.
DR InParanoid; Q28808; -.
DR TreeFam; TF340510; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:HGNC-UCL.
DR GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0098586; P:cellular response to virus; ISS:UniProtKB.
DR GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR GO; GO:0097193; P:intrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:HGNC-UCL.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISS:HGNC.
DR GO; GO:0051902; P:negative regulation of mitochondrial depolarization; ISS:HGNC-UCL.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; ISS:UniProtKB.
DR GO; GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0001836; P:release of cytochrome c from mitochondria; ISS:HGNC-UCL.
DR Gene3D; 6.10.110.10; -; 1.
DR InterPro; IPR009311; IFI6/IFI27-like.
DR InterPro; IPR038213; IFI6/IFI27-like_sf.
DR PANTHER; PTHR16932; PTHR16932; 1.
DR Pfam; PF06140; Ifi-6-16; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Apoptosis; Immunity; Innate immunity; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..130
FT /note="Interferon alpha-inducible protein 6"
FT /id="PRO_0000008742"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 130 AA; 12929 MW; CD2D992A59202EF4 CRC64;
MRQKAVSLFL CYLLLFTCSG VEAGKKKCSE SSDSGSGFWK ALTFMAVGGG LAVAGLPALG
FTGAGIAANS VAASLMSWSA ILNGGGVPAG GLVATLQSLG AGGSSVITGN IGALMGYATH
KYLDSEEDEE
