IFI8_MOUSE
ID IFI8_MOUSE Reviewed; 588 AA.
AC Q3V3Q4; Q8BLW5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Inteferon-activable protein 208 {ECO:0000305};
DE AltName: Full=Interferon activated gene 208 {ECO:0000312|MGI:MGI:2442822};
DE AltName: Full=Interferon-activable protein 204-like;
DE Short=Ifi-204-like;
DE AltName: Full=Pyrin domain-containing protein 3 {ECO:0000312|MGI:MGI:2442822};
GN Name=Ifi208 {ECO:0000312|MGI:MGI:2442822};
GN Synonyms=Pydc3 {ECO:0000312|MGI:MGI:2442822};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Aorta, Bone, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SIMILARITY: Belongs to the HIN-200 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK041099; BAC30821.1; -; mRNA.
DR EMBL; AK036671; BAE43297.1; -; mRNA.
DR CCDS; CCDS48451.1; -.
DR RefSeq; NP_001156410.1; NM_001162938.1.
DR AlphaFoldDB; Q3V3Q4; -.
DR SMR; Q3V3Q4; -.
DR BioGRID; 780105; 3.
DR STRING; 10090.ENSMUSP00000083039; -.
DR EPD; Q3V3Q4; -.
DR jPOST; Q3V3Q4; -.
DR PaxDb; Q3V3Q4; -.
DR PRIDE; Q3V3Q4; -.
DR ProteomicsDB; 300364; -.
DR Ensembl; ENSMUST00000085876; ENSMUSP00000083039; ENSMUSG00000066677.
DR Ensembl; ENSMUST00000169857; ENSMUSP00000128958; ENSMUSG00000066677.
DR GeneID; 100033459; -.
DR KEGG; mmu:100033459; -.
DR UCSC; uc007drt.1; mouse.
DR CTD; 100033459; -.
DR MGI; MGI:2442822; Ifi208.
DR VEuPathDB; HostDB:ENSMUSG00000066677; -.
DR eggNOG; ENOG502QTQS; Eukaryota.
DR GeneTree; ENSGT00390000013296; -.
DR HOGENOM; CLU_465355_0_0_1; -.
DR InParanoid; Q3V3Q4; -.
DR OrthoDB; 1577634at2759; -.
DR PhylomeDB; Q3V3Q4; -.
DR TreeFam; TF337385; -.
DR BioGRID-ORCS; 100033459; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Ifi208; mouse.
DR PRO; PR:Q3V3Q4; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3V3Q4; protein.
DR Bgee; ENSMUSG00000066677; Expressed in thymus and 24 other tissues.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0035458; P:cellular response to interferon-beta; IBA:GO_Central.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR PANTHER; PTHR12200; PTHR12200; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR PROSITE; PS50824; DAPIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..588
FT /note="Inteferon-activable protein 208"
FT /id="PRO_0000334522"
FT DOMAIN 5..92
FT /note="Pyrin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00061"
FT REGION 157..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 63866 MW; 6DCF91A5E71AC05F CRC64;
MTGEMVNYYK QIVLLSGLEY MNDYNFRALK SLLNHDLKLT KNMQDDYDRI KIADLMEEKF
PEDAGLSKLI EVCEDIPELA ARVDILRKEM EKVKNKTKIK SESSPLPLTS SLMEAWEVEP
AMVTASSEES KDTIPESPDT MTTQFLEEKP KFPLLSATST SQAEGEPLTP QRFPTTASSS
LQTPLEPTEI LSTILATSQG SSAPYSTCDK SSRVPPVTVS SSLQTIQTCQ ATSTLPCSHH
TSLESPKTEP SSVQATQMTQ AIKASGHNCP QVPASAVSSS FIKPQVTPAM LLSGVQTPLM
PQATVPSRAQ TFQLTPAKMT SGCNSPQMSA ATVYSSYSNP QVTPVHSSVQ ILQMNLAAMT
IGCNSPHVSA ATVSSPYNNP WVTPATFPRN AQTLQLYPAA MAHACNSPQV SAATISSSYN
NTPQVSSVTV PRSFPAMSLS PAKPLKAKIG SHLGATDQLV KDHQFEDNEM QNPQSGLGTG
LSDQPRLSRT QSRTEKRRRK QEEQPLATKM KRLSLSPPQT TARRVNPMPT WGQLKKLTRE
AEGLVQRTGN KLSSETMFLA MLALIAMQSS SEICNYDKGG HSGTSSEK
