IFIX_MOUSE
ID IFIX_MOUSE Reviewed; 420 AA.
AC Q8BV49; Q3KNA6; Q3KNA7; Q8BLY5; Q8BVS6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Pyrin and HIN domain-containing protein 1;
DE AltName: Full=Interferon-inducible protein 209;
DE Short=Ifi-209;
DE AltName: Full=Interferon-inducible protein X;
DE AltName: Full=Interferon-inducible protein p209;
GN Name=Pyhin1 {ECO:0000312|MGI:MGI:2138243}; Synonyms=Ifi209, Ifix;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Aorta, Bone marrow, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6NCr; TISSUE=Hematopoietic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=15896773; DOI=10.1016/j.yexcr.2005.03.032;
RA Ludlow L.E.A., Johnstone R.W., Clarke C.J.P.;
RT "The HIN-200 family: more than interferon-inducible genes?";
RL Exp. Cell Res. 308:1-17(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HIN-200 family. {ECO:0000305}.
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DR EMBL; AK040884; BAC30731.1; -; mRNA.
DR EMBL; AK076726; BAC36457.1; -; mRNA.
DR EMBL; AK080371; BAC37894.1; -; mRNA.
DR EMBL; AK150817; BAE29880.1; -; mRNA.
DR EMBL; BC096384; AAH96384.1; -; mRNA.
DR EMBL; BC107378; AAI07379.1; -; mRNA.
DR EMBL; BC107379; AAI07380.1; -; mRNA.
DR CCDS; CCDS35791.1; -.
DR RefSeq; NP_778191.1; NM_175026.3.
DR AlphaFoldDB; Q8BV49; -.
DR SMR; Q8BV49; -.
DR BioGRID; 231754; 1.
DR STRING; 10090.ENSMUSP00000061900; -.
DR iPTMnet; Q8BV49; -.
DR PhosphoSitePlus; Q8BV49; -.
DR EPD; Q8BV49; -.
DR jPOST; Q8BV49; -.
DR MaxQB; Q8BV49; -.
DR PaxDb; Q8BV49; -.
DR PeptideAtlas; Q8BV49; -.
DR PRIDE; Q8BV49; -.
DR ProteomicsDB; 266952; -.
DR DNASU; 236312; -.
DR Ensembl; ENSMUST00000056071; ENSMUSP00000061900; ENSMUSG00000043263.
DR GeneID; 236312; -.
DR KEGG; mmu:236312; -.
DR UCSC; uc007drr.2; mouse.
DR CTD; 236312; -.
DR MGI; MGI:2138243; Ifi209.
DR VEuPathDB; HostDB:ENSMUSG00000043263; -.
DR eggNOG; ENOG502QTQS; Eukaryota.
DR GeneTree; ENSGT00390000013296; -.
DR HOGENOM; CLU_020123_2_0_1; -.
DR InParanoid; Q8BV49; -.
DR OMA; QMEVIVY; -.
DR OrthoDB; 1304994at2759; -.
DR PhylomeDB; Q8BV49; -.
DR TreeFam; TF337385; -.
DR BioGRID-ORCS; 236312; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q8BV49; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8BV49; protein.
DR Bgee; ENSMUSG00000043263; Expressed in peripheral lymph node and 72 other tissues.
DR ExpressionAtlas; Q8BV49; baseline and differential.
DR Genevisible; Q8BV49; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0035458; P:cellular response to interferon-beta; IDA:MGI.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 2.40.50.140; -; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200; PTHR12200; 2.
DR Pfam; PF02760; HIN; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50834; HIN_200; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..420
FT /note="Pyrin and HIN domain-containing protein 1"
FT /id="PRO_0000334525"
FT DOMAIN 1..87
FT /note="Pyrin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00061"
FT DOMAIN 219..416
FT /note="HIN-200"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00106"
FT REGION 82..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..99
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 85
FT /note="K -> M (in Ref. 2; AAI07379/AAI07380)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="E -> V (in Ref. 2; AAI07380)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="Y -> H (in Ref. 1; BAC30731)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="Y -> C (in Ref. 1; BAC30731)"
FT /evidence="ECO:0000305"
FT CONFLICT 313
FT /note="E -> D (in Ref. 2; AAI07380)"
FT /evidence="ECO:0000305"
FT CONFLICT 338
FT /note="K -> R (in Ref. 2; AAI07380)"
FT /evidence="ECO:0000305"
FT CONFLICT 418
FT /note="A -> T (in Ref. 2; AAI07380)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 420 AA; 46887 MW; A1983C4F11956A8D CRC64;
MVNEYKRIVL LTGLMGINDH DFRMVKSLLS KELKLNRMQD QYDRVKIADL MEDKFPKDAG
VDQLIKLYKQ IPGLGDIANK LKNEKAKAKR TRTGKRKTAA KRQRQEEPST SQPMSTTNED
AEPESGRSTP DTQVAQLSLP TASRRNQAIQ ISPTIASSSG QTSSRSSETL QSIIQSPKTP
KRPSSSILDP PVSSGTASSS AQALGVPLAT IAKRQRLKNV PKEPSEENGH QQGSKKVMVL
KVTEPFSYDV TEEKMFHATV ATETEFFRVK VFDIVLKEKF IPNKVLTISN YVGCNGFINI
YSASSVSEVN DGEPMNIPLS LRKSANRTPK INYLCSKKRG IFVNGVFTVC KKEEKWNYIC
YEIGDDTGMM EVEVYGRLTN IACNPGDKLR LICFKLIPDE EKAQLRSTTH SNMQVIKAKN
