IFM10_HUMAN
ID IFM10_HUMAN Reviewed; 228 AA.
AC A6NMD0; A6NEU7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Interferon-induced transmembrane protein 10;
DE AltName: Full=Dispanin subfamily A member 3;
DE Short=DSPA3;
GN Name=IFITM10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-228.
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP GENE FAMILY.
RX PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT "The dispanins: a novel gene family of ancient origin that contains 14
RT human members.";
RL PLoS ONE 7:E31961-E31961(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-99 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF82263.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC068580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK289574; BAF82263.1; ALT_INIT; mRNA.
DR CCDS; CCDS53593.2; -.
DR RefSeq; NP_001164291.2; NM_001170820.3.
DR AlphaFoldDB; A6NMD0; -.
DR BioGRID; 135557; 2.
DR STRING; 9606.ENSP00000344430; -.
DR iPTMnet; A6NMD0; -.
DR PhosphoSitePlus; A6NMD0; -.
DR BioMuta; IFITM10; -.
DR MassIVE; A6NMD0; -.
DR PaxDb; A6NMD0; -.
DR PeptideAtlas; A6NMD0; -.
DR PRIDE; A6NMD0; -.
DR DNASU; 402778; -.
DR Ensembl; ENST00000340134.5; ENSP00000344430.4; ENSG00000244242.2.
DR GeneID; 402778; -.
DR KEGG; hsa:402778; -.
DR MANE-Select; ENST00000340134.5; ENSP00000344430.4; NM_001170820.4; NP_001164291.2.
DR UCSC; uc021qbs.3; human.
DR CTD; 402778; -.
DR DisGeNET; 402778; -.
DR GeneCards; IFITM10; -.
DR HGNC; HGNC:40022; IFITM10.
DR HPA; ENSG00000244242; Group enriched (adrenal gland, bone marrow, brain, choroid plexus, retina).
DR MIM; 618293; gene.
DR neXtProt; NX_A6NMD0; -.
DR OpenTargets; ENSG00000244242; -.
DR VEuPathDB; HostDB:ENSG00000244242; -.
DR eggNOG; ENOG502SJYU; Eukaryota.
DR GeneTree; ENSGT00950000182857; -.
DR HOGENOM; CLU_088800_0_0_1; -.
DR InParanoid; A6NMD0; -.
DR OMA; KGCKGDS; -.
DR OrthoDB; 1555189at2759; -.
DR PhylomeDB; A6NMD0; -.
DR TreeFam; TF334894; -.
DR PathwayCommons; A6NMD0; -.
DR BioGRID-ORCS; 402778; 8 hits in 1059 CRISPR screens.
DR ChiTaRS; IFITM10; human.
DR Pharos; A6NMD0; Tdark.
DR PRO; PR:A6NMD0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NMD0; protein.
DR Bgee; ENSG00000244242; Expressed in left adrenal gland cortex and 93 other tissues.
DR ExpressionAtlas; A6NMD0; baseline and differential.
DR Genevisible; A6NMD0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR Pfam; PF04505; CD225; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..228
FT /note="Interferon-induced transmembrane protein 10"
FT /id="PRO_0000332961"
FT TOPO_DOM 1..154
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..228
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 29..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 167
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 168
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 228 AA; 24599 MW; 112635627E7E76A0 CRC64;
MREGKRGPPC ILSFRGTLER VEAQWELEAQ GPGQCPAPLG DPASTTDGAQ EARVPLDGAF
WIPRPPAGSP KGCFACVSKP PALQAPAAPA PEPSASPPMA PTLFPMESKS SKTDSVRAAG
APPACKHLAE KKTMTNPTTV IEVYPDTTEV NDYYLWSIFN FVYLNFCCLG FIALAYSLKV
RDKKLLNDLN GAVEDAKTAR LFNITSSALA ASCIILVFIF LRYPLTDY
