IFM10_MOUSE
ID IFM10_MOUSE Reviewed; 201 AA.
AC Q8BR26; Q810P6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Interferon-induced transmembrane protein 10;
DE AltName: Full=Dispanin subfamily A member 3;
DE Short=DSPA3;
GN Name=Ifitm10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT "The dispanins: a novel gene family of ancient origin that contains 14
RT human members.";
RL PLoS ONE 7:E31961-E31961(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BR26-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BR26-2; Sequence=VSP_041596;
CC Name=3;
CC IsoId=Q8BR26-3; Sequence=VSP_041596, VSP_033398;
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
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DR EMBL; AK045822; BAC32504.1; -; mRNA.
DR EMBL; AK163573; BAE37402.1; -; mRNA.
DR EMBL; AC034099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049666; AAH49666.1; -; mRNA.
DR CCDS; CCDS40191.1; -. [Q8BR26-3]
DR CCDS; CCDS85467.1; -. [Q8BR26-2]
DR CCDS; CCDS85468.1; -. [Q8BR26-1]
DR RefSeq; NP_001334470.1; NM_001347541.1. [Q8BR26-1]
DR RefSeq; NP_001334471.1; NM_001347542.1. [Q8BR26-2]
DR RefSeq; NP_796239.1; NM_177265.4. [Q8BR26-3]
DR RefSeq; XP_011240310.1; XM_011242008.2. [Q8BR26-3]
DR RefSeq; XP_011240312.1; XM_011242010.2. [Q8BR26-3]
DR RefSeq; XP_011240313.1; XM_011242011.2. [Q8BR26-3]
DR RefSeq; XP_011240314.1; XM_011242012.1. [Q8BR26-3]
DR AlphaFoldDB; Q8BR26; -.
DR STRING; 10090.ENSMUSP00000062728; -.
DR iPTMnet; Q8BR26; -.
DR PhosphoSitePlus; Q8BR26; -.
DR PaxDb; Q8BR26; -.
DR PRIDE; Q8BR26; -.
DR ProteomicsDB; 267276; -. [Q8BR26-1]
DR ProteomicsDB; 267277; -. [Q8BR26-2]
DR ProteomicsDB; 267278; -. [Q8BR26-3]
DR DNASU; 320802; -.
DR Ensembl; ENSMUST00000059223; ENSMUSP00000062728; ENSMUSG00000045777. [Q8BR26-3]
DR Ensembl; ENSMUST00000084412; ENSMUSP00000081450; ENSMUSG00000045777. [Q8BR26-2]
DR Ensembl; ENSMUST00000105988; ENSMUSP00000101608; ENSMUSG00000045777. [Q8BR26-1]
DR GeneID; 320802; -.
DR KEGG; mmu:320802; -.
DR UCSC; uc009kmt.1; mouse. [Q8BR26-3]
DR UCSC; uc009kmu.1; mouse. [Q8BR26-1]
DR CTD; 402778; -.
DR MGI; MGI:2444776; Ifitm10.
DR VEuPathDB; HostDB:ENSMUSG00000045777; -.
DR eggNOG; ENOG502SJYU; Eukaryota.
DR GeneTree; ENSGT00950000182857; -.
DR HOGENOM; CLU_1634855_0_0_1; -.
DR InParanoid; Q8BR26; -.
DR OMA; KGCKGDS; -.
DR OrthoDB; 1555189at2759; -.
DR PhylomeDB; Q8BR26; -.
DR BioGRID-ORCS; 320802; 1 hit in 25 CRISPR screens.
DR ChiTaRS; Ifitm10; mouse.
DR PRO; PR:Q8BR26; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BR26; protein.
DR Bgee; ENSMUSG00000045777; Expressed in facial nucleus and 132 other tissues.
DR Genevisible; Q8BR26; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR Pfam; PF04505; CD225; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..201
FT /note="Interferon-induced transmembrane protein 10"
FT /id="PRO_0000332962"
FT TOPO_DOM 1..127
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..173
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 140
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 141
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..71
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_041596"
FT VAR_SEQ 153..201
FT /note="VRDKKLLNDLNGAVEDAKTARLFNITSSALAASCIILIFIFLRYPLTDY ->
FT RTLTNTNRGKKGCLATQDTSALCCLLQGAHPEEGDGAICYVRDHRACVVGHTYNPSPGE
FT AEEGTWMAQRDNTFEKNSAQHC (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033398"
SQ SEQUENCE 201 AA; 21555 MW; 6520EF6E5E746D41 CRC64;
MAQGPSQCPA LLGAPASTTD GTQEARVPLD GAFWIPRPPA GSPKGCFACV SKPPALQAAA
APAPEPSASP PMAPTLFPME SKSSKTDSVR ASGVPQACKH LAEKKTMTNP TTVIEVYPDT
TEVNDYYLWS IFNFVYLNFC CLGFIALAYS LKVRDKKLLN DLNGAVEDAK TARLFNITSS
ALAASCIILI FIFLRYPLTD Y
