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IFM1_HUMAN
ID   IFM1_HUMAN              Reviewed;         125 AA.
AC   P13164; Q15322; Q53XZ0;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 3.
DT   03-AUG-2022, entry version 179.
DE   RecName: Full=Interferon-induced transmembrane protein 1 {ECO:0000305};
DE   AltName: Full=Dispanin subfamily A member 2a;
DE            Short=DSPA2a;
DE   AltName: Full=Interferon-induced protein 17;
DE   AltName: Full=Interferon-inducible protein 9-27;
DE   AltName: Full=Leu-13 antigen;
DE   AltName: CD_antigen=CD225;
GN   Name=IFITM1 {ECO:0000312|HGNC:HGNC:5412}; Synonyms=CD225, IFI17;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-13.
RX   PubMed=2492664; DOI=10.1073/pnas.86.3.840;
RA   Reid L.E., Brasnett A.H., Gilbert C.S., Porter A.C.G., Gewert D.R.,
RA   Stark G.R., Kerr I.M.;
RT   "A single DNA response element can confer inducibility by both alpha- and
RT   gamma-interferons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:840-844(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-13.
RX   PubMed=7559564; DOI=10.1074/jbc.270.40.23860;
RA   Deblandre G.A., Marinx O.P., Evans S.S., Majjaj S., Leo O., Caput D.,
RA   Huez G.A., Wathelet M.G.;
RT   "Expression cloning of an interferon-inducible 17-kDa membrane protein
RT   implicated in the control of cell growth.";
RL   J. Biol. Chem. 270:23860-23866(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-13.
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-13.
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-13.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-13.
RC   TISSUE=Cervix;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   INTERACTION WITH CD81.
RX   PubMed=2398277;
RA   Takahashi S., Doss C., Levy S., Levy R.;
RT   "TAPA-1, the target of an antiproliferative antibody, is associated on the
RT   cell surface with the Leu-13 antigen.";
RL   J. Immunol. 145:2207-2213(1990).
RN   [9]
RP   IDENTIFICATION IN A COMPLEX WITH CR2; CD81 AND CD19, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=1383329;
RA   Bradbury L.E., Kansas G.S., Levy S., Evans R.L., Tedder T.F.;
RT   "The CD19/CD21 signal transducing complex of human B lymphocytes includes
RT   the target of antiproliferative antibody-1 and Leu-13 molecules.";
RL   J. Immunol. 149:2841-2850(1992).
RN   [10]
RP   FUNCTION.
RX   PubMed=16847454; DOI=10.1038/sj.onc.1209807;
RA   Yang G., Xu Y., Chen X., Hu G.;
RT   "IFITM1 plays an essential role in the antiproliferative action of
RT   interferon-gamma.";
RL   Oncogene 26:594-603(2007).
RN   [11]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH CAV1.
RX   PubMed=19499152; DOI=10.1093/abbs/gmp034;
RA   Xu Y., Yang G., Hu G.;
RT   "Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK
RT   activation.";
RL   Acta Biochim. Biophys. Sin. 41:488-494(2009).
RN   [12]
RP   FUNCTION IN VIRAL RESISTANCE.
RX   PubMed=20064371; DOI=10.1016/j.cell.2009.12.017;
RA   Brass A.L., Huang I.C., Benita Y., John S.P., Krishnan M.N., Feeley E.M.,
RA   Ryan B.J., Weyer J.L., van der Weyden L., Fikrig E., Adams D.J.,
RA   Xavier R.J., Farzan M., Elledge S.J.;
RT   "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus,
RT   West Nile virus, and dengue virus.";
RL   Cell 139:1243-1254(2009).
RN   [13]
RP   REVIEW.
RX   PubMed=21166591; DOI=10.1089/jir.2010.0112;
RA   Siegrist F., Ebeling M., Certa U.;
RT   "The small interferon-induced transmembrane genes and proteins.";
RL   J. Interferon Cytokine Res. 31:183-197(2011).
RN   [14]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=20838853; DOI=10.1007/s11060-010-0377-4;
RA   Yu F., Ng S.S., Chow B.K., Sze J., Lu G., Poon W.S., Kung H.F., Lin M.C.;
RT   "Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits
RT   proliferation, migration, and invasion of glioma cells.";
RL   J. Neurooncol. 103:187-195(2011).
RN   [15]
RP   FUNCTION.
RX   PubMed=21177806; DOI=10.1128/jvi.01531-10;
RA   Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.;
RT   "The IFITM proteins inhibit HIV-1 infection.";
RL   J. Virol. 85:2126-2137(2011).
RN   [16]
RP   ERRATUM OF PUBMED:21177806.
RA   Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.;
RL   J. Virol. 85:4043-4043(2011).
RN   [17]
RP   FUNCTION.
RX   PubMed=21976647; DOI=10.1128/jvi.05633-11;
RA   Raychoudhuri A., Shrivastava S., Steele R., Kim H., Ray R., Ray R.B.;
RT   "ISG56 and IFITM1 proteins inhibit hepatitis C virus replication.";
RL   J. Virol. 85:12881-12889(2011).
RN   [18]
RP   FUNCTION.
RX   PubMed=21253575; DOI=10.1371/journal.ppat.1001258;
RA   Huang I.C., Bailey C.C., Weyer J.L., Radoshitzky S.R., Becker M.M.,
RA   Chiang J.J., Brass A.L., Ahmed A.A., Chi X., Dong L., Longobardi L.E.,
RA   Boltz D., Kuhn J.H., Elledge S.J., Bavari S., Denison M.R., Choe H.,
RA   Farzan M.;
RT   "Distinct patterns of IFITM-mediated restriction of filoviruses, SARS
RT   coronavirus, and influenza A virus.";
RL   PLoS Pathog. 7:E1001258-E1001258(2011).
RN   [19]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=22634173; DOI=10.1016/j.bone.2012.05.012;
RA   Kim B.S., Kim H.J., Kim J.S., You Y.O., Zadeh H., Shin H.I., Lee S.J.,
RA   Park Y.J., Takata T., Pi S.H., Lee J., You H.K.;
RT   "IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone
RT   marrow stromal cells.";
RL   Bone 51:506-514(2012).
RN   [20]
RP   FUNCTION.
RX   PubMed=22479637; DOI=10.1371/journal.pone.0034508;
RA   Chan Y.K., Huang I.C., Farzan M.;
RT   "IFITM proteins restrict antibody-dependent enhancement of dengue virus
RT   infection.";
RL   PLoS ONE 7:E34508-E34508(2012).
RN   [21]
RP   GENE FAMILY.
RX   PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA   Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT   "The dispanins: a novel gene family of ancient origin that contains 14
RT   human members.";
RL   PLoS ONE 7:E31961-E31961(2012).
RN   [22]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, VARIANT [LARGE SCALE
RP   ANALYSIS] ALA-13, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP   ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [23]
RP   SUBCELLULAR LOCATION, AND TOPOLOGY.
RX   PubMed=25105503; DOI=10.1371/journal.pone.0104341;
RA   Weston S., Czieso S., White I.J., Smith S.E., Kellam P., Marsh M.;
RT   "A membrane topology model for human interferon inducible transmembrane
RT   protein 1.";
RL   PLoS ONE 9:E104341-E104341(2014).
RN   [24]
RP   FUNCTION, SUBCELLULAR LOCATION, PALMITOYLATION AT CYS-50; CYS-51 AND
RP   CYS-84, AND MUTAGENESIS OF 50-CYS-CYS-51 AND CYS-84.
RX   PubMed=26354436; DOI=10.1074/jbc.m115.657346;
RA   Narayana S.K., Helbig K.J., McCartney E.M., Eyre N.S., Bull R.A.,
RA   Eltahla A., Lloyd A.R., Beard M.R.;
RT   "The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3
RT   Inhibit Hepatitis C Virus Entry.";
RL   J. Biol. Chem. 290:25946-25959(2015).
RN   [25]
RP   FUNCTION (MICROBIAL INFECTION).
RX   PubMed=33051876; DOI=10.15252/embj.2020106267;
RA   Buchrieser J., Dufloo J., Hubert M., Monel B., Planas D., Rajah M.M.,
RA   Planchais C., Porrot F., Guivel-Benhassine F., Van der Werf S.,
RA   Casartelli N., Mouquet H., Bruel T., Schwartz O.;
RT   "Syncytia formation by SARS-CoV-2-infected cells.";
RL   EMBO J. 39:e106267-e106267(2020).
RN   [26]
RP   ERRATUM OF PUBMED:33051876.
RX   PubMed=33522642; DOI=10.15252/embj.2020107405;
RA   Buchrieser J., Dufloo J., Hubert M., Monel B., Planas D., Rajah M.M.,
RA   Planchais C., Porrot F., Guivel-Benhassine F., Van der Werf S.,
RA   Casartelli N., Mouquet H., Bruel T., Schwartz O.;
RT   "Syncytia formation by SARS-CoV-2-infected cells.";
RL   EMBO J. 40:e107405-e107405(2021).
RN   [27]
RP   FUNCTION.
RX   PubMed=33270927; DOI=10.15252/embj.2020106501;
RA   Shi G., Kenney A.D., Kudryashova E., Zani A., Zhang L., Lai K.K.,
RA   Hall-Stoodley L., Robinson R.T., Kudryashov D.S., Compton A.A., Yount J.S.;
RT   "Opposing activities of IFITM proteins in SARS-CoV-2 infection.";
RL   EMBO J. 40:e106501-e106501(2021).
RN   [28]
RP   VARIANT [LARGE SCALE ANALYSIS] ALA-13, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: IFN-induced antiviral protein which inhibits the entry of
CC       viruses to the host cell cytoplasm, permitting endocytosis, but
CC       preventing subsequent viral fusion and release of viral contents into
CC       the cytosol. Active against multiple viruses, including influenza A
CC       virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus
CC       (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV),
CC       human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV)
CC       (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus
CC       hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-
CC       mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated
CC       viral entry. Also implicated in cell adhesion and control of cell
CC       growth and migration (PubMed:33270927). Inhibits SARS-CoV-2 S protein-
CC       mediated syncytia formation (PubMed:33051876). Plays a key role in the
CC       antiproliferative action of IFN-gamma either by inhibiting the ERK
CC       activation or by arresting cell growth in G1 phase in a p53-dependent
CC       manner. Acts as a positive regulator of osteoblast differentiation. In
CC       hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV
CC       infection by targeting the endocytosed HCV virion for lysosomal
CC       degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV
CC       activity that may complement the anti-HCV activity of IFITM1 by
CC       inhibiting the late stages of HCV entry, possibly in a coordinated
CC       manner by trapping the virion in the endosomal pathway and targeting it
CC       for degradation at the lysosome (PubMed:26354436).
CC       {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371,
CC       ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:21177806,
CC       ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:21976647,
CC       ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:22634173,
CC       ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33051876,
CC       ECO:0000269|PubMed:33270927}.
CC   -!- SUBUNIT: Interacts with CD81 (PubMed:2398277, PubMed:26354436). Part of
CC       a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the
CC       membrane of mature B-cells (PubMed:1383329). Interacts with CAV1; this
CC       interaction enhances the ability of CAV1 in inhibiting ERK activation
CC       (PubMed:19499152). {ECO:0000269|PubMed:1383329,
CC       ECO:0000269|PubMed:19499152, ECO:0000269|PubMed:2398277,
CC       ECO:0000269|PubMed:26354436}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1383329,
CC       ECO:0000269|PubMed:19499152, ECO:0000269|PubMed:25105503,
CC       ECO:0000269|PubMed:26354436}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:19499152}. Lysosome membrane
CC       {ECO:0000269|PubMed:26354436}.
CC   -!- TISSUE SPECIFICITY: Bone (at protein level). Levels greatly elevated in
CC       colon cancer, cervical cancer, esophageal cancer and ovarian cancer.
CC       Expressed in glioma cell lines. {ECO:0000269|PubMed:20838853,
CC       ECO:0000269|PubMed:22634173}.
CC   -!- INDUCTION: By IFN-alpha and IFNG/IFN-gamma.
CC   -!- PTM: Palmitoylation on membrane-proximal cysteines controls clustering
CC       in membrane compartments and antiviral activity.
CC       {ECO:0000305|PubMed:26354436}.
CC   -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
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DR   EMBL; J04164; AAA35494.1; -; mRNA.
DR   EMBL; X84958; CAA59337.1; -; mRNA.
DR   EMBL; BT007173; AAP35837.1; -; mRNA.
DR   EMBL; AK290480; BAF83169.1; -; mRNA.
DR   EMBL; AC136475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471278; EAW61218.1; -; Genomic_DNA.
DR   EMBL; BC000897; AAH00897.1; -; mRNA.
DR   CCDS; CCDS41584.1; -.
DR   PIR; A31454; A31454.
DR   RefSeq; NP_003632.3; NM_003641.3.
DR   AlphaFoldDB; P13164; -.
DR   BioGRID; 114091; 359.
DR   DIP; DIP-32672N; -.
DR   IntAct; P13164; 9.
DR   MINT; P13164; -.
DR   STRING; 9606.ENSP00000386187; -.
DR   TCDB; 8.A.58.1.1; the dispanin (dispanin) family.
DR   iPTMnet; P13164; -.
DR   PhosphoSitePlus; P13164; -.
DR   SwissPalm; P13164; -.
DR   BioMuta; IFITM1; -.
DR   DMDM; 215274118; -.
DR   EPD; P13164; -.
DR   jPOST; P13164; -.
DR   MassIVE; P13164; -.
DR   MaxQB; P13164; -.
DR   PaxDb; P13164; -.
DR   PeptideAtlas; P13164; -.
DR   PRIDE; P13164; -.
DR   ProteomicsDB; 52897; -.
DR   TopDownProteomics; P13164; -.
DR   Antibodypedia; 1282; 386 antibodies from 38 providers.
DR   DNASU; 8519; -.
DR   Ensembl; ENST00000328221.5; ENSP00000330825.5; ENSG00000185885.17.
DR   Ensembl; ENST00000408968.4; ENSP00000386187.3; ENSG00000185885.17.
DR   Ensembl; ENST00000528780.5; ENSP00000437057.1; ENSG00000185885.17.
DR   Ensembl; ENST00000680588.1; ENSP00000505380.1; ENSG00000185885.17.
DR   GeneID; 8519; -.
DR   KEGG; hsa:8519; -.
DR   MANE-Select; ENST00000408968.4; ENSP00000386187.3; NM_003641.5; NP_003632.4.
DR   UCSC; uc001loy.5; human.
DR   CTD; 8519; -.
DR   DisGeNET; 8519; -.
DR   GeneCards; IFITM1; -.
DR   HGNC; HGNC:5412; IFITM1.
DR   HPA; ENSG00000185885; Low tissue specificity.
DR   MIM; 604456; gene.
DR   neXtProt; NX_P13164; -.
DR   OpenTargets; ENSG00000185885; -.
DR   PharmGKB; PA29653; -.
DR   VEuPathDB; HostDB:ENSG00000185885; -.
DR   eggNOG; ENOG502S9XK; Eukaryota.
DR   GeneTree; ENSGT00950000182857; -.
DR   HOGENOM; CLU_124511_3_0_1; -.
DR   InParanoid; P13164; -.
DR   OMA; YGSVAIY; -.
DR   OrthoDB; 1555189at2759; -.
DR   PhylomeDB; P13164; -.
DR   TreeFam; TF334894; -.
DR   PathwayCommons; P13164; -.
DR   Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   SignaLink; P13164; -.
DR   BioGRID-ORCS; 8519; 10 hits in 1075 CRISPR screens.
DR   ChiTaRS; IFITM1; human.
DR   GeneWiki; IFITM1; -.
DR   GenomeRNAi; 8519; -.
DR   Pharos; P13164; Tbio.
DR   PRO; PR:P13164; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; P13164; protein.
DR   Bgee; ENSG00000185885; Expressed in right ovary and 197 other tissues.
DR   Genevisible; P13164; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0032991; C:protein-containing complex; IDA:MGI.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR   GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR   GO; GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:UniProtKB.
DR   GO; GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB.
DR   GO; GO:0045071; P:negative regulation of viral genome replication; IDA:UniProtKB.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   GO; GO:0045669; P:positive regulation of osteoblast differentiation; IMP:UniProtKB.
DR   GO; GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
DR   GO; GO:0035456; P:response to interferon-beta; IDA:UniProtKB.
DR   GO; GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
DR   GO; GO:0009615; P:response to virus; IDA:UniProtKB.
DR   GO; GO:0060337; P:type I interferon signaling pathway; IBA:GO_Central.
DR   InterPro; IPR007593; CD225/Dispanin_fam.
DR   Pfam; PF04505; CD225; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense; Cell membrane; Immunity; Innate immunity; Lipoprotein;
KW   Lysosome; Membrane; Osteogenesis; Palmitate; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..125
FT                   /note="Interferon-induced transmembrane protein 1"
FT                   /id="PRO_0000153727"
FT   TOPO_DOM        1..36
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000303|PubMed:25105503"
FT   TOPO_DOM        58..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..125
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          84..125
FT                   /note="Interaction with CAV1"
FT                   /evidence="ECO:0000269|PubMed:19499152"
FT   MOD_RES         16
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   LIPID           50
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000305|PubMed:26354436"
FT   LIPID           51
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000305|PubMed:26354436"
FT   LIPID           84
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000305|PubMed:26354436"
FT   VARIANT         13
FT                   /note="P -> A (in dbSNP:rs9667990)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:2492664,
FT                   ECO:0000269|PubMed:7559564, ECO:0000269|Ref.3,
FT                   ECO:0000269|Ref.6, ECO:0007744|PubMed:21269460,
FT                   ECO:0007744|PubMed:23186163"
FT                   /id="VAR_047422"
FT   MUTAGEN         50..51
FT                   /note="CC->AA: No effect on anti-HCV activity. Only
FT                   localizes at the lysosome."
FT                   /evidence="ECO:0000269|PubMed:26354436"
FT   MUTAGEN         84
FT                   /note="C->A: Loss of anti-HCV activity. Only localizes at
FT                   the lysosome."
FT                   /evidence="ECO:0000269|PubMed:26354436"
FT   CONFLICT        103
FT                   /note="L -> S (in Ref. 1; AAA35494)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   125 AA;  13964 MW;  10EE5B64894838ED CRC64;
     MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDHVVWS LFNTLFLNWC CLGFIAFAYS
     VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTIGF ILLLVFGSVT VYHIMLQIIQ
     EKRGY
 
 
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