IFN14_HUMAN
ID IFN14_HUMAN Reviewed; 189 AA.
AC P01570; Q5VZ56; Q7M4S1;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 3.
DT 03-AUG-2022, entry version 198.
DE RecName: Full=Interferon alpha-14;
DE Short=IFN-alpha-14;
DE AltName: Full=Interferon alpha-H;
DE Short=LeIF H;
DE AltName: Full=Interferon lambda-2-H;
DE Flags: Precursor;
GN Name=IFNA14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6163083; DOI=10.1038/290020a0;
RA Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R.,
RA Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.;
RT "The structure of eight distinct cloned human leukocyte interferon cDNAs.";
RL Nature 290:20-26(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6165082; DOI=10.1126/science.6165082;
RA Lawn R.M., Adelman J., Dull T.J., Gross M., Goeddel D.V., Ullrich A.;
RT "DNA sequence of two closely linked human leukocyte interferon genes.";
RL Science 212:1159-1162(1981).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=4057246; DOI=10.1016/0022-2836(85)90401-2;
RA Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J.,
RA Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M.,
RA Nagata S., Weissmann C.;
RT "Structural relationship of human interferon alpha genes and pseudogenes.";
RL J. Mol. Biol. 185:227-260(1985).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 24-55, AND FUNCTION.
RX PubMed=1634550; DOI=10.1016/s0021-9258(18)42167-9;
RA Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C.,
RA Nguyen N.Y., Hu R.-Q.;
RT "Purification and characterization of multiple components of human
RT lymphoblastoid interferon-alpha.";
RL J. Biol. Chem. 267:15210-15216(1992).
RN [8]
RP PROTEIN SEQUENCE OF 24-53, AND GLYCOSYLATION AT ASN-95.
RX PubMed=9425112; DOI=10.1042/bj3290295;
RA Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.;
RT "Identification of nine interferon-alpha subtypes produced by Sendai virus-
RT induced human peripheral blood leucocytes.";
RL Biochem. J. 329:295-302(1998).
RN [9]
RP PROTEIN SEQUENCE OF 24-43.
RX PubMed=7765487; DOI=10.1271/bbb.58.1714;
RA Shirono H., Koga J., Uemura H., Matsuo A.;
RT "Identification of glycosylated subtypes of interferon-alpha produced by
RT human leukocytes.";
RL Biosci. Biotechnol. Biochem. 58:1714-1715(1994).
RN [10]
RP ABSENCE OF POLYMORPHISM.
RX PubMed=8910771; DOI=10.1089/jir.1996.16.853;
RA Hussain M., Gill D.S., Liao M.-J.;
RT "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in
RT the genome of a large human population.";
RL J. Interferon Cytokine Res. 16:853-859(1996).
CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC Interferon stimulates the production of two enzymes: a protein kinase
CC and an oligoadenylate synthetase. {ECO:0000269|PubMed:1634550}.
CC -!- INTERACTION:
CC P01570; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12290903, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; V00542; CAA23803.1; -; mRNA.
DR EMBL; V00533; CAA23794.1; -; Genomic_DNA.
DR EMBL; X02959; CAA26705.1; -; Genomic_DNA.
DR EMBL; AL162420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471071; EAW58616.1; -; Genomic_DNA.
DR EMBL; BC074956; AAH74956.1; -; mRNA.
DR EMBL; BC104159; AAI04160.1; -; mRNA.
DR EMBL; BC104160; AAI04161.1; -; mRNA.
DR CCDS; CCDS6501.1; -.
DR PIR; A42753; A42753.
DR PIR; A92916; IVHU14.
DR RefSeq; NP_002163.2; NM_002172.2.
DR AlphaFoldDB; P01570; -.
DR SMR; P01570; -.
DR BioGRID; 109671; 16.
DR ComplexPortal; CPX-6003; Interferon alpha receptor-ligand complex, IFNA14 variant.
DR IntAct; P01570; 9.
DR STRING; 9606.ENSP00000369571; -.
DR ChEMBL; CHEMBL3856161; -.
DR GlyConnect; 288; 2 N-Linked glycans.
DR GlyGen; P01570; 2 sites, 4 N-linked glycans (2 sites).
DR iPTMnet; P01570; -.
DR PhosphoSitePlus; P01570; -.
DR BioMuta; IFNA14; -.
DR DMDM; 20178265; -.
DR REPRODUCTION-2DPAGE; P01570; -.
DR MassIVE; P01570; -.
DR PaxDb; P01570; -.
DR PeptideAtlas; P01570; -.
DR PRIDE; P01570; -.
DR ABCD; P01570; 2 sequenced antibodies.
DR Antibodypedia; 24865; 165 antibodies from 17 providers.
DR DNASU; 3448; -.
DR Ensembl; ENST00000380222.4; ENSP00000369571.2; ENSG00000228083.3.
DR GeneID; 3448; -.
DR KEGG; hsa:3448; -.
DR MANE-Select; ENST00000380222.4; ENSP00000369571.2; NM_002172.3; NP_002163.2.
DR UCSC; uc010mis.4; human.
DR CTD; 3448; -.
DR DisGeNET; 3448; -.
DR GeneCards; IFNA14; -.
DR HGNC; HGNC:5420; IFNA14.
DR HPA; ENSG00000228083; Not detected.
DR MIM; 147579; gene.
DR neXtProt; NX_P01570; -.
DR OpenTargets; ENSG00000228083; -.
DR PharmGKB; PA29659; -.
DR VEuPathDB; HostDB:ENSG00000228083; -.
DR eggNOG; ENOG502SQAC; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_0_0_1; -.
DR InParanoid; P01570; -.
DR OMA; NNRRTLM; -.
DR OrthoDB; 1011028at2759; -.
DR PhylomeDB; P01570; -.
DR TreeFam; TF336177; -.
DR PathwayCommons; P01570; -.
DR Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR Reactome; R-HSA-912694; Regulation of IFNA/IFNB signaling.
DR Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation.
DR Reactome; R-HSA-9705671; SARS-CoV-2 activates/modulates innate and adaptive immune responses.
DR Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production.
DR SignaLink; P01570; -.
DR BioGRID-ORCS; 3448; 9 hits in 993 CRISPR screens.
DR GeneWiki; IFNA14; -.
DR GenomeRNAi; 3448; -.
DR Pharos; P01570; Tbio.
DR PRO; PR:P01570; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; P01570; protein.
DR Bgee; ENSG00000228083; Expressed in metanephros cortex.
DR Genevisible; P01570; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005126; F:cytokine receptor binding; TAS:ProtInc.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0098586; P:cellular response to virus; IC:ComplexPortal.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0060337; P:type I interferon signaling pathway; IC:ComplexPortal.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 1: Evidence at protein level;
KW Antiviral defense; Cytokine; Direct protein sequencing; Disulfide bond;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:1634550,
FT ECO:0000269|PubMed:7765487, ECO:0000269|PubMed:9425112"
FT CHAIN 24..189
FT /note="Interferon alpha-14"
FT /id="PRO_0000016367"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:9425112"
FT DISULFID 24..122
FT /evidence="ECO:0000250"
FT DISULFID 52..162
FT /evidence="ECO:0000250"
FT CONFLICT 175
FT /note="L -> F (in Ref. 1; CAA23803)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 189 AA; 22063 MW; B6B71E2F0D644FE7 CRC64;
MALPFALMMA LVVLSCKSSC SLGCNLSQTH SLNNRRTLML MAQMRRISPF SCLKDRHDFE
FPQEEFDGNQ FQKAQAISVL HEMMQQTFNL FSTKNSSAAW DETLLEKFYI ELFQQMNDLE
ACVIQEVGVE ETPLMNEDSI LAVKKYFQRI TLYLMEKKYS PCAWEVVRAE IMRSLSFSTN
LQKRLRRKD
