ID   IFN16_HUMAN             Reviewed;         189 AA.
AC   P05015; Q5VV12;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 186.
DE   RecName: Full=Interferon alpha-16;
DE            Short=IFN-alpha-16;
DE   AltName: Full=Interferon alpha-WA;
DE   Flags: Precursor;
GN   Name=IFNA16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=4057246; DOI=10.1016/0022-2836(85)90401-2;
RA   Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J.,
RA   Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M.,
RA   Nagata S., Weissmann C.;
RT   "Structural relationship of human interferon alpha genes and pseudogenes.";
RL   J. Mol. Biol. 185:227-260(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6387705; DOI=10.1073/pnas.81.20.6451;
RA   Torczynski R.M., Fuke M., Bollon A.P.;
RT   "Human genomic library screened with 17-base oligonucleotide probes yields
RT   a novel interferon gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:6451-6455(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6548765; DOI=10.1089/jir.1984.4.609;
RA   Gren E., Berzin V.M., Jansone I., Tsimanis A., Vishnevsky Y., Apsalons U.;
RT   "Novel human leukocyte interferon subtype and structural comparison of
RT   alpha interferon genes.";
RL   J. Interferon Res. 4:609-617(1984).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase.
CC   -!- INTERACTION:
CC       P05015; O14964: HGS; NbExp=3; IntAct=EBI-7055360, EBI-740220;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; X02957; CAA26703.1; -; Genomic_DNA.
DR   EMBL; K02055; AAA52727.1; -; Genomic_DNA.
DR   EMBL; M28585; AAA36042.1; -; mRNA.
DR   EMBL; AL512606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58618.1; -; Genomic_DNA.
DR   CCDS; CCDS34996.1; -.
DR   PIR; G23753; IVHU16.
DR   RefSeq; NP_002164.1; NM_002173.3.
DR   AlphaFoldDB; P05015; -.
DR   SMR; P05015; -.
DR   BioGRID; 109672; 55.
DR   ComplexPortal; CPX-6004; Interferon alpha receptor-ligand complex, IFNA16 variant.
DR   IntAct; P05015; 2.
DR   MINT; P05015; -.
DR   STRING; 9606.ENSP00000369564; -.
DR   ChEMBL; CHEMBL3856161; -.
DR   iPTMnet; P05015; -.
DR   PhosphoSitePlus; P05015; -.
DR   BioMuta; IFNA16; -.
DR   DMDM; 124463; -.
DR   jPOST; P05015; -.
DR   MassIVE; P05015; -.
DR   PaxDb; P05015; -.
DR   PeptideAtlas; P05015; -.
DR   PRIDE; P05015; -.
DR   TopDownProteomics; P05015; -.
DR   ABCD; P05015; 2 sequenced antibodies.
DR   Antibodypedia; 24859; 103 antibodies from 19 providers.
DR   DNASU; 3449; -.
DR   Ensembl; ENST00000380216.1; ENSP00000369564.1; ENSG00000147885.4.
DR   GeneID; 3449; -.
DR   KEGG; hsa:3449; -.
DR   MANE-Select; ENST00000380216.1; ENSP00000369564.1; NM_002173.3; NP_002164.1.
DR   UCSC; uc003zor.1; human.
DR   CTD; 3449; -.
DR   DisGeNET; 3449; -.
DR   GeneCards; IFNA16; -.
DR   HGNC; HGNC:5421; IFNA16.
DR   HPA; ENSG00000147885; Not detected.
DR   MIM; 147580; gene.
DR   neXtProt; NX_P05015; -.
DR   OpenTargets; ENSG00000147885; -.
DR   PharmGKB; PA29660; -.
DR   VEuPathDB; HostDB:ENSG00000147885; -.
DR   eggNOG; ENOG502SQAC; Eukaryota.
DR   GeneTree; ENSGT01000000214430; -.
DR   HOGENOM; CLU_109427_0_0_1; -.
DR   InParanoid; P05015; -.
DR   OMA; LDNRKTM; -.
DR   OrthoDB; 1358010at2759; -.
DR   PhylomeDB; P05015; -.
DR   TreeFam; TF336177; -.
DR   PathwayCommons; P05015; -.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   Reactome; R-HSA-912694; Regulation of IFNA/IFNB signaling.
DR   Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation.
DR   Reactome; R-HSA-9705671; SARS-CoV-2 activates/modulates innate and adaptive immune responses.
DR   Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production.
DR   SignaLink; P05015; -.
DR   BioGRID-ORCS; 3449; 12 hits in 991 CRISPR screens.
DR   GeneWiki; IFNA16; -.
DR   GenomeRNAi; 3449; -.
DR   Pharos; P05015; Tdark.
DR   PRO; PR:P05015; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; P05015; protein.
DR   Bgee; ENSG00000147885; Expressed in cell and 1 other tissue.
DR   Genevisible; P05015; HS.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0098586; P:cellular response to virus; IC:ComplexPortal.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon signaling pathway; IC:ComplexPortal.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..189
FT                   /note="Interferon alpha-16"
FT                   /id="PRO_0000016368"
FT   DISULFID        24..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..162
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   189 AA;  21711 MW;  FC8822F787F1585F CRC64;
     MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF SCLKDRYDFG
     FPQEVFDGNQ FQKAQAISAF HEMIQQTFNL FSTKDSSAAW DETLLDKFYI ELFQQLNDLE
     ACVTQEVGVE EIALMNEDSI LAVRKYFQRI TLYLMGKKYS PCAWEVVRAE IMRSFSFSTN
     LQKGLRRKD