ID   IFNA1_BOVIN             Reviewed;         189 AA.
AC   P07348;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Interferon alpha-1;
DE   Flags: Precursor;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Pancreas;
RX   PubMed=2985969; DOI=10.1128/mcb.5.4.768-779.1985;
RA   Capon D.J., Shepard H.M., Goeddel D.V.;
RT   "Two distinct families of human and bovine interferon-alpha genes are
RT   coordinately expressed and encode functional polypeptides.";
RL   Mol. Cell. Biol. 5:768-779(1985).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; M11001; AAA30577.1; -; Genomic_DNA.
DR   PIR; A23285; IVBOI1.
DR   AlphaFoldDB; P07348; -.
DR   SMR; P07348; -.
DR   STRING; 9913.ENSBTAP00000055837; -.
DR   PaxDb; P07348; -.
DR   eggNOG; ENOG502SQAC; Eukaryota.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..189
FT                   /note="Interferon alpha-1"
FT                   /id="PRO_0000016384"
FT   DISULFID        24..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..162
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   189 AA;  21406 MW;  58FB5FD9485A2E12 CRC64;
     MAPAWSLLLA LLLLSCNAIC SLGCHLPHSH SLAKRRVLTL LRQLRRVSPS SCLQDRNDFA
     FPQEALGGSQ LQKAQAISVL HEVTQHTFQL FSTEGSAAVW DESLLDRLRT ALDQQLTDLQ
     ACLRQEEGLP GAPLLKEDSS LAVRKYFHRL TLYLQEKRHS PCAWEVVRAQ VMRAFSSSTN
     LQERFRRKD